CaltechAUTHORS
  A Caltech Library Service

Redox signaling through DNA by metalloproteins

Barton, Jacqueline K. (2013) Redox signaling through DNA by metalloproteins. In: 245th ACS National Meeting & Exposition, Abstracts of Papers, April 7-11, 2013, New Orleans, LA. https://resolver.caltech.edu/CaltechAUTHORS:20130722-132209522

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20130722-132209522

Abstract

Many expts. have now shown that DNA-mediated charge transport can arise over long mol. distances but in a reaction that is exquisitely sensitive to perturbations in the DNA base stack. Indeed, DNA charge transport chem. reports on the integrity of the DNA helix. Increasingly, proteins involved in DNA replication and repair have been found to contain 4Fe-4S clusters, common redox cofactors in biol. DNA-modified electrodes have been utilized to det. redox potentials for these metalloproteins bound to DNA; this electrochem. establishes the ability of the metalloproteins to carry out redox chem. at physiol. potentials in the DNAbound form. Studies are also described to characterize how these DNA-binding proteins contg. 4Fe-4S clusters may utilize DNA charge transport chem. for long range signaling.


Item Type:Conference or Workshop Item (Paper)
Related URLs:
URLURL TypeDescription
http://presentations.acs.org/common/tracks.aspx/Spring2013OrganizationUNSPECIFIED
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2013 American Chemical Society.
Record Number:CaltechAUTHORS:20130722-132209522
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130722-132209522
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39500
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Jul 2013 22:37
Last Modified:03 Oct 2019 05:07

Repository Staff Only: item control page