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Flexible neurocage array for live neural network study

Park, Jungwook and Pine, Jerome and Tai, Yu-Chong (2013) Flexible neurocage array for live neural network study. In: IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE , Piscataway, NJ, pp. 295-298. ISBN 978-1-4673-5654-1. https://resolver.caltech.edu/CaltechAUTHORS:20130729-091911111

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Abstract

A flexible multi-electrode-array (MEA) with parylene-C (PA-C) cages on PA-C substrate for neural network study in vitro is presented here. 8×8 cage arrays were fabricated on a 10-μm-thick PA-C film. For our use, the array was glued on a 100μm-thick glass substrate for ease of handling. Each cage is to trap an individual neuron to force a close proximity of the neuron to an embedded electrode inside the cage for stimulation and recording. In addition, each neurocage has six tunnels emanating from the cage to allow axons and dendrites to grow outward and form synapses with other trapped neurons. The Electrode inside each neurocage can then be used to stimulate and/or record electrical activity from the trapped cell at any given time. Why thin and flexible? From our previous work, it is learned that manually loading neuron one-by-one into the cage is time-consuming. We then propose to use laser tweezer to do the cell loading from the backside of the array. To facilitate laser tweezer neuron loading, the neurocage array must be transparent and thin. On the other hand, device flexibility facilitates a high-yield fabrication, easy singulation and attachment to almost any substrate for use.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/MEMSYS.2013.6474236 DOIArticle
http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6474236PublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2013 IEEE.
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INSPEC Accession Number13369880
Record Number:CaltechAUTHORS:20130729-091911111
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130729-091911111
Official Citation:Jungwook Park; Pine, J.; Yu-Chong Tai, "Flexible neurocage array for live neural network study," Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on , vol., no., pp.295,298, 20-24 Jan. 2013 doi: 10.1109/MEMSYS.2013.6474236
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39617
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Jul 2013 21:38
Last Modified:03 Oct 2019 05:09

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