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Effects of Pulvinar Inactivation on Spatial Decision-making between Equal and Asymmetric Reward Options

Wilke, Melanie and Kagan, Igor and Andersen, Richard A. (2013) Effects of Pulvinar Inactivation on Spatial Decision-making between Equal and Asymmetric Reward Options. Journal of Cognitive Neuroscience, 25 (8). pp. 1270-1283. ISSN 0898-929X. doi:10.1162/jocn_a_00399. https://resolver.caltech.edu/CaltechAUTHORS:20130802-110449966

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Abstract

The ability to selectively process visual inputs and to decide between multiple movement options in an adaptive manner is critical for survival. Such decisions are known to be influenced by factors such as reward expectation and visual saliency. The dorsal pulvinar connects to a multitude of cortical areas that are involved in visuospatial memory and integrate information about upcoming eye movements with expected reward values. However, it is unclear whether the dorsal pulvinar is critically involved in spatial memory and reward-based oculomotor decision behavior. To examine this, we reversibly inactivated the dorsal portion of the pulvinar while monkeys performed a delayed memory saccade task that included choices between equally or unequally rewarded options. Pulvinar inactivation resulted in a delay of saccade initiation toward memorized contralesional targets but did not affect spatial memory. Furthermore, pulvinar inactivation caused a pronounced choice bias toward the ipsilesional hemifield when the reward value in the two hemifields was equal. However, this choice bias could be alleviated by placing a high reward target into the contralesional hemifield. The bias was less affected by the manipulation of relative visual saliency between the two competing targets. These results suggest that the dorsal pulvinar is involved in determining the behavioral desirability of movement goals while being less critical for spatial memory and reward processing.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1162/jocn_a_00399 DOIArticle
ORCID:
AuthorORCID
Kagan, Igor0000-0002-1814-4200
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2013 Massachusetts Institute of Technology. Posted Online June 27, 2013. We thank K. Pejsa and N. Sammons for animal care and Dr. V. Shcherbatyuk for computer support. This work was supported by Moore Foundation, National Eye Institute, National Science Foundation, Defense Advanced Research Projects Agency, and Boswell Foundation (to R. A.) and the Herman and Lilly Schilling Foundation (to M. W.).
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
National Eye InstituteUNSPECIFIED
NSFUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Boswell FoundationUNSPECIFIED
Herman and Lilly Schilling FoundationUNSPECIFIED
Issue or Number:8
DOI:10.1162/jocn_a_00399
Record Number:CaltechAUTHORS:20130802-110449966
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130802-110449966
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39732
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Aug 2013 20:31
Last Modified:09 Nov 2021 23:46

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