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Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex

Chib, V. S. and Yun, K. and Takahashi, H. and Shimojo, S. (2013) Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex. Translational Psychiatry, 3 . Art. No. e268. ISSN 2158-3188. PMCID PMC3693403.

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The midbrain lies deep within the brain and has an important role in reward, motivation, movement and the pathophysiology of various neuropsychiatric disorders such as Parkinson’s disease, schizophrenia, depression and addiction. To date, the primary means of acting on this region has been with pharmacological interventions or implanted electrodes. Here we introduce a new noninvasive brain stimulation technique that exploits the highly interconnected nature of the midbrain and prefrontal cortex to stimulate deep brain regions. Using transcranial direct current stimulation (tDCS) of the prefrontal cortex, we were able to remotely activate the interconnected midbrain and cause increases in participants’ appraisals of facial attractiveness. Participants with more enhanced prefrontal/midbrain connectivity following stimulation exhibited greater increases in attractiveness ratings. These results illustrate that noninvasive direct stimulation of prefrontal cortex can induce neural activity in the distally connected midbrain, which directly effects behavior. Furthermore, these results suggest that this tDCS protocol could provide a promising approach to modulate midbrain functions that are disrupted in neuropsychiatric disorders.

Item Type:Article
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URLURL TypeDescription 10.1038/tp.2013.44DOIArticle CentralArticle
Chib, V. S.0000-0001-8810-5699
Yun, K.0000-0002-6103-7187
Additional Information:© 2013 Macmillan Publishers Limited. Translational Psychiatry is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. Received 18 December 2012; revised 4 March 2013; accepted 8 April 2013. This work was funded by grants from the JST.ERATO, JST.CREST and the Caltech/Tamagawa gCOE to SS. HT was funded by a Japan-US. Brain Research Cooperation Program grant, and Grants-in- Aid for Scientific Research (23120009, 2368004) by MEXT, Japan.
Funding AgencyGrant Number
Japan Science and Technology AgencyUNSPECIFIED
Caltech/Tamagawa gCOEUNSPECIFIED
Japan-US. Brain Research Cooperation ProgramUNSPECIFIED
Ministry of Education, Culture, Sports, Science and Technology (MEXT)23120009
Ministry of Education, Culture, Sports, Science and Technology (MEXT)23680045
Tamagawa University Global Centers of ExcellenceUNSPECIFIED
Subject Keywords:brain stimulation; midbrain; preference; prefrontal cortex; transcranial direct current stimulation (tDCS)
PubMed Central ID:PMC3693403
Record Number:CaltechAUTHORS:20130805-090529070
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39752
Deposited By: Tony Diaz
Deposited On:06 Aug 2013 18:48
Last Modified:03 Aug 2020 22:36

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