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Innate immune recognition of the microbiota promotes host-microbial symbiosis

Chu, Hiutung and Mazmanian, Sarkis K. (2013) Innate immune recognition of the microbiota promotes host-microbial symbiosis. Nature Immunology, 14 (7). pp. 668-675. ISSN 1529-2908. PMCID PMC4109969. doi:10.1038/ni.2635. https://resolver.caltech.edu/CaltechAUTHORS:20130808-093222275

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Abstract

Pattern-recognition receptors (PRRs) are traditionally known to sense microbial molecules during infection to initiate inflammatory responses. However, ligands for PRRs are not exclusive to pathogens and are abundantly produced by the resident microbiota during normal colonization. Mechanism(s) that underlie this paradox have remained unclear. Recent studies reveal that gut bacterial ligands from the microbiota signal through PRRs to promote development of host tissue and the immune system, and protection from disease. Evidence from both invertebrate and vertebrate models reveals that innate immune receptors are required to promote long-term colonization by the microbiota. This emerging perspective challenges current models in immunology and suggests that PRRs may have evolved, in part, to mediate the bidirectional cross-talk between microbial symbionts and their hosts.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/ni.2635 DOIArticle
http://www.nature.com/ni/journal/v14/n7/full/ni.2635.htmlPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109969/PubMed CentralArticle
http://rdcu.be/cm3VPublisherFree ReadCube access
ORCID:
AuthorORCID
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. Received 8 April; accepted 2 May; published online 18 June 2013. We thank A. Khosravi, S.W. McBride, G. Sharon, Y. Lee and M. Flajnik for comments on the manuscript. Supported by the Burroughs Wellcome Fund, Crohn’s and Colitis Foundation and US National Institutes of Health (DK078938 and GM099535).
Funders:
Funding AgencyGrant Number
Burroughs Wellcome FundUNSPECIFIED
Crohn's and Colitis FoundationUNSPECIFIED
NIHDK078938
NIHGM099535
Issue or Number:7
PubMed Central ID:PMC4109969
DOI:10.1038/ni.2635
Record Number:CaltechAUTHORS:20130808-093222275
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130808-093222275
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39814
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Aug 2013 21:22
Last Modified:09 Nov 2021 23:47

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