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GATA-3 locks the door to the B-cell option

Rothenberg, Ellen V. (2013) GATA-3 locks the door to the B-cell option. Blood, 121 (10). pp. 1673-1674. ISSN 0006-4971. PMCID PMC3591792. doi:10.1182/blood-2013-01-477737. https://resolver.caltech.edu/CaltechAUTHORS:20130809-091457588

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Abstract

T-cell early developmental stages and alternative options: GATA-3 is depicted as an intrathymically induced, specific inhibitor of access to the B-lineage pathway. Recognized stages in early intrathymic T-cell development are shown, along with the degrees of access to the B-cell program and other alternative programs that the cells can demonstrate at these stages if the extrinsic barrier of Notch/Dll4 signaling (red line) is removed. Red bricks represent GATA-3 when expressed at critical levels, and purple bricks represent other T-lineage commitment factors (eg, Bcl11b) that are activated later. Not shown are the positive roles of GATA-3 that permit the efficient generation of DN2 cells. Full commitment is complete by the DN2b stage.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1182/blood-2013-01-477737 DOIArticle
http://bloodjournal.hematologylibrary.org/content/121/10/1673PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591792/PubMed CentralArticle
ORCID:
AuthorORCID
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2013 American Society of Hematology.
Issue or Number:10
PubMed Central ID:PMC3591792
DOI:10.1182/blood-2013-01-477737
Record Number:CaltechAUTHORS:20130809-091457588
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130809-091457588
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39829
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Aug 2013 21:00
Last Modified:09 Nov 2021 23:47

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