Rothenberg, Ellen V. (2013) GATA-3 locks the door to the B-cell option. Blood, 121 (10). pp. 1673-1674. ISSN 0006-4971. PMCID PMC3591792. doi:10.1182/blood-2013-01-477737. https://resolver.caltech.edu/CaltechAUTHORS:20130809-091457588
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Abstract
T-cell early developmental stages and alternative options: GATA-3 is depicted as an intrathymically induced, specific inhibitor of access to the B-lineage pathway. Recognized stages in early intrathymic T-cell development are shown, along with the degrees of access to the B-cell program and other alternative programs that the cells can demonstrate at these stages if the extrinsic barrier of Notch/Dll4 signaling (red line) is removed. Red bricks represent GATA-3 when expressed at critical levels, and purple bricks represent other T-lineage commitment factors (eg, Bcl11b) that are activated later. Not shown are the positive roles of GATA-3 that permit the efficient generation of DN2 cells. Full commitment is complete by the DN2b stage.
Item Type: | Article | ||||||||||||
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Additional Information: | © 2013 American Society of Hematology. | ||||||||||||
Issue or Number: | 10 | ||||||||||||
PubMed Central ID: | PMC3591792 | ||||||||||||
DOI: | 10.1182/blood-2013-01-477737 | ||||||||||||
Record Number: | CaltechAUTHORS:20130809-091457588 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20130809-091457588 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 39829 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 12 Aug 2013 21:00 | ||||||||||||
Last Modified: | 09 Nov 2021 23:47 |
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