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Recurrent excitation in neocortical cells

Douglas, Rodney J. and Koch, Christof and Mahowald, Misha and Martin, Kevan A. C. and Suarez, Humbert H, (1995) Recurrent excitation in neocortical cells. Science, 269 (5226). pp. 981-985. ISSN 0036-8075. doi:10.1126/science.7638624.

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The majority of synapses in the mammalian cortex originate from cortical neurons. Indeed, the largest input to cortical cells comes from neighboring excitatory cells. However, most models of cortical development and processing do not reflect the anatomy and physiology of feedback excitation and are restricted to serial feedforward excitation. This report describes how populations of neurons in cat visual cortex can use excitatory feedback, characterized as an effective "network conductance", to amplify their feedforward input signals and demonstrates how neuronal discharge can be kept proportional to stimulus strength despite strong, recurrent connections that threaten to cause runaway excitation. These principles are incorporated into models of cortical direction and orientation selectivity that emphasize the basic design principles of cortical architectures.

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Koch, Christof0000-0001-6482-8067
Additional Information: 16 February 1995; accepted 5 June 1995. We thank the U.S. Office of Naval Research for their long-term support of this work. In addition this work was supported by the Air Force Office of Scientific Research, the Gatsby Foundation, the Medical Research Council, the National Institute of Mental Health, the National Science Foundation, the European Community, the Human Frontiers Science Program, the Wellcome Trust, and the Royal Society. We thank J. Anderson for reconstructions of neurons in cat striate cortex and G. Holt for help with the graphics.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
U.S. Office of Naval ResearchUNSPECIFIED
U.S. Air Force Office of Scientific ResearchUNSPECIFIED
Gatsby FoundationUNSPECIFIED
Medical Research CouncilUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
National Science FoundationUNSPECIFIED
European CommunityUNSPECIFIED
Human Frontiers Science ProgramUNSPECIFIED
Issue or Number:5226
Record Number:CaltechAUTHORS:20130816-103139423
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40361
Deposited By: KLAB Import
Deposited On:11 Mar 2010 06:06
Last Modified:09 Nov 2021 23:48

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