Koch, Christof and Poggio, Tomaso (1985) The biophysical properties of spines as a basis for their electrical function: a comment on Kawato and Tsukahara (1983). Journal of Theoretical Biology, 113 (2). pp. 225-229. ISSN 0022-5193. https://resolver.caltech.edu/CaltechAUTHORS:20130816-103203326
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Abstract
In a theoretical study of the passive cable properties of dendritic spines Kawato & Tsukahara (1983) claim to have proved that “the dendritic spine has no significant electrical function” (from their discussion). However, Kawato & Tsukahara restrict their analysis to current inputs to spines. Since the dimensions of spines are very small, their input resistance is expected to be very large and the synaptic input to spines has to be modeled as conductance change. Under this assumption, spines show interesting (non-linear) electrical properties: i) the somatic potential induced by an excitatory synapse on a spine may depend strongly on the shape of the spine and ii) the effect of inhibition might be confined to the spine.
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| Additional Information: | © 1985 Academic Press Inc. (London) Ltd. Received 27 February 1984. Available online 14 July 2006. BARRETT, J. N. & CRILL, W. E. (1974). 1. Physio/. 239, 325. BuTZ, E. G. & CowAN, J.D. (1974). Biophys. J. 14,661. CRICK, F. (1982). Trends Neurosci. 5, 44. 229 DIAMOND, J., GRAY, E. G. & YASARGIL, G. M. ( 1970). In: Excitatory synaptic mechanisms. (Andersen, P. & Jansen, J. eds). Oslo: Universitetsforlag. GAGE, P. W. & McBURNEY, R. N. ( 1972). 1. Physio/., Lond. 226, 79. HORWITZ, B. (1983). Soc. Neurosci. Abst. 9, 321. JACK, J. J., NoBLE, D. & TSIEN, R. W. ( 1974). Electric current flow in excitable cells. Oxford: Clarendon Press. KAWATO, M. & TSUKAHARA, N. (1983). 1. theor. Bioi. 103, 507. KOCH, C. & POGGIO, T. ( 1983a). Trends Neurosci. 6, 80. KocH, C. & PoGGIO, T. (1983b). Proc. R. Soc. Lond., B 218, 455. PERKEL, D. H. (1983). 1. Physio/., Paris 78,695. RALL, W. ( 1974}. In: Cellular Mechanisms subserving Changes in Neuronal Activity. (Woody, C. D., Brown, K. A., Crow, Jr, T. J. & Knispel, J. D. eds.). Los Angeles: University of California. RALL, W. ( 1978). In: Studies in Neurophy::io/ogy. (Porter, R. ed.). Cambridge: Cambridge University Press. RALL, W. & RINZEL, J. (1974). Biophys. 1. 14,759. TURNER, D. A. (1984). Biophys. 1. 46, 85. | |||||||||
| Group: | Koch Laboratory (KLAB) | |||||||||
| Issue or Number: | 2 | |||||||||
| Record Number: | CaltechAUTHORS:20130816-103203326 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20130816-103203326 | |||||||||
| Official Citation: | Christof Koch, Tomaso Poggio, The biophysical properties of spines as a basis for their electrical function: a comment on Kawato & Tsukahara (1983), Journal of Theoretical Biology, Volume 113, Issue 2, 21 March 1985, Pages 225-229, ISSN 0022-5193, http://dx.doi.org/10.1016/S0022-5193(85)80225-3. (http://www.sciencedirect.com/science/article/pii/S0022519385802253) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 40427 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | KLAB Import | |||||||||
| Deposited On: | 11 Mar 2010 06:03 | |||||||||
| Last Modified: | 03 Oct 2019 05:13 |
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