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Local Field Potentials and Spikes in the Human Medial Temporal Lobe are Selective to Image Category

Kraskov, Alexander and Quian Quiroga, Rodrigo and Reddy, Leila and Fried, Itzhak and Koch, Christof (2007) Local Field Potentials and Spikes in the Human Medial Temporal Lobe are Selective to Image Category. Journal of Cognitive Neuroscience, 19 (3). pp. 479-492. ISSN 0898-929X. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103210294

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Abstract

Local field potentials (LFPs) reflect the averaged dendrosomatic activity of synaptic signals of large neuronal populations. In this study, we investigate the selectivity of LFPs and single neuron activity to semantic categories of visual stimuli in the medial temporal lobe of nine neurosurgical patients implanted with intracranial depth electrodes for clinical reasons. Strong selectivity to the category of presented images was found for the amplitude of LFPs in 8% of implanted microelectrodes and for the firing rates of single and multiunits in 14% of microelectrodes. There was little overlap between the LFP- and spike-selective microelectrodes. Separate analysis of the power and phase of LFPs revealed that the mean phase was category-selective around the θ frequency range and that the power of the LFPs was category-selective for high frequencies around the γ rhythm. Of the 36 microelectrodes with amplitude-selective LFPs, 30 were found in the hippocampus. Finally, it was possible to readout information about the category of stimuli presented to the patients with both spikes and LFPs. Combining spiking and LFP activity enhanced the decoding accuracy in comparison with the accuracy obtained with each signal alone, especially for short time intervals.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1162/jocn.2007.19.3.479DOIArticle
http://www.mitpressjournals.org/doi/abs/10.1162/jocn.2007.19.3.479PublisherArticle
ORCID:
AuthorORCID
Fried, Itzhak0000-0002-5962-2678
Koch, Christof0000-0001-6482-8067
Additional Information:c2007 Massachusetts Institute of Technology. We thank all patients for their participation and Eric Behnke, Tony Fields, Emily Ho, Eve Isham, and Charles Wilson for technical assistance. We also would like to thank Gabriel Kreiman and Daniel Rizzuto for helpful discussions. This work was supported by grants from the NINDS, NIMH, NSF, DARPA, EPSRC, the Office of Naval Research, the W.M. Keck Foundation Fund for Discovery in Basic Medical Research, the Gordon Moore Foundation, the Sloan Foundation, and the Swartz Foundation for Computational Neuroscience.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
NSFUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Engineering and Physical Sciences Research Council (EPSRC)UNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
W. M. Keck FoundationUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Swartz Foundation for Computational NeuroscienceUNSPECIFIED
Record Number:CaltechAUTHORS:20130816-103210294
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103210294
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40456
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:12 Jan 2008 01:58
Last Modified:30 Oct 2017 21:07

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