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Coding efficiency and information rates in transmembrane signaling

Prank, Klaus and Gabbiani, Fabrizio and Brabant, Georg (2000) Coding efficiency and information rates in transmembrane signaling. Biosystems, 55 (1-3). pp. 15-22. ISSN 0303-2647. doi:10.1016/S0303-2647(99)00078-7.

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A variety of cell types responds to hormonal stimuli by repetitive spikes in the intracellular concentration of calcium ([Ca<sup>2+</sup>]i) which have been demonstrated to encode information in their frequency, amplitude, and duration. These [Ca<sup>2+</sup>]i-spike trains are able to specifically regulate distinct cellular functions. Using a mathematical model for receptor-controlled [Ca<sup>2+</sup>]i oscillations in hepatocytes we investigate the encoding of fluctuating hormonal signals in [Ca<sup>2+</sup>]i-spike trains. The transmembrane information transfer is quantified by using an information-theoretic reverse-engineering approach which allows to reconstruct the dynamic hormonal stimulus from the [Ca<sup>2+</sup>]i-spike trains. This approach allows to estimate the accuracy of coding as well as the rate of transmembrane information transfer. We found that up to 87% of the dynamic stimulus information can be encoded in the [Ca<sup>2+</sup>]i-spike train at a maximum information transfer rate of 1.1 bit per [Ca<sup>2+</sup>]i-spike. These numerical results for humoral information transfer are in the same order as in a number of sensory neuronal systems despite several orders of magnitude different time scales of operation suggesting a universal principle of information processing in both biological systems.

Item Type:Article
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Gabbiani, Fabrizio0000-0003-4966-3027
Additional Information:© 2000 Elsevier Science. This work was supported by DFG under grants Pr 333:12–1 and Br 915:4–4.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)Pr 333:12–1
Deutsche Forschungsgemeinschaft (DFG)Br 915:4–4
Subject Keywords:Intracellular calcium oscillations; Hepatocyte; Stimulus reconstruction; Information rate; Frequency coding; Temporal coding
Issue or Number:1-3
Record Number:CaltechAUTHORS:20130816-103221325
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40494
Deposited By: KLAB Import
Deposited On:11 Mar 2010 06:00
Last Modified:09 Nov 2021 23:49

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