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A Single-Neuron Correlate of Change Detection and Change Blindness in the Human Medial Temporal Lobe

Reddy, Leila and Quian Quiroga, Rodrigo and Wilken, Patrick and Koch, Christof and Fried, Itzhak (2006) A Single-Neuron Correlate of Change Detection and Change Blindness in the Human Medial Temporal Lobe. Current Biology, 16 (20). pp. 2066-2072. ISSN 0960-9822. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103223634

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Abstract

Observers are often unaware of changes in their visual environment when attention is not focused at the location of the change [1,2,3,4]. Because of its rather intriguing nature, this phenomenon, known as change blindness, has been extensively studied with psychophysics [5,6,7] as well as with fMRI [8,9,10,11]. However, whether change blindness can be tracked in the activity of single cells is not clear. To explore the neural correlates of change detection and change blindness, we recorded from single neurons in the human medial temporal lobe (MTL) during a change-detection paradigm. The preferred pictures of the visually responsive units elicited significantly higher firing rates on the attended trials when subjects correctly identified a change (change detection) compared to the unattended trials when they missed it (change blindness). On correct trials, the firing activity of individual units allowed us to predict the occurrence of a change, on a trial-by-trial basis, with 67% accuracy. In contrast, this prediction was at chance for incorrect, unattended trials. The firing rates of visually selective MTL cells thus constitute a neural correlate of change detection.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cub.2006.08.064DOIArticle
http://www.sciencedirect.com/science/article/pii/S0960982206021312PublisherArticle
http://www.cell.com/current-biology/supplemental/S0960-9822%2806%2902131-2PublisherSupplemental material
ORCID:
AuthorORCID
Koch, Christof0000-0001-6482-8067
Fried, Itzhak0000-0002-5962-2678
Additional Information:Copyright © 2006 Elsevier Ltd. Received: March 31, 2006. Revised: August 29, 2006. Accepted: August 29, 2006. Published: October 23, 2006. We thank all the patients for their participation; I. Wainwright and B. Salaz for administrative assistance; E. Behnke, T. Fields, E. Ho, E. Isham, A. Kraskov, P. Steinmetz, and C. Wilson for technical assistance; and R. VanRullen for comments on the manuscript. This work was supported by grants from the National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH), National Science Foundation (NSF), Defense Advanced Research Projects Agency (DARPA), the Office of Naval Research, the W.M. Keck Fund for Discovery in Basic Medical Research, the Gordon Moore Foundation, the Sloan Foundation, and the Swartz Foundation for Computational Neuroscience.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
National Institute of Mental Health (NIMH) UNSPECIFIED
NSFUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
W. M. Keck FoundationUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Swartz Foundation for Computational NeuroscienceUNSPECIFIED
Non-Subject Keywords:SYSNEURO
Record Number:CaltechAUTHORS:20130816-103223634
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103223634
Official Citation:: Leila Reddy et al., A Single-Neuron Correlate of Change Detection and Change Blindness in the Human Medial Temporal Lobe, Current Biology (2006), doi:10.1016/j.cub.2006.08.064
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40501
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:12 Jan 2008 02:05
Last Modified:30 Oct 2017 21:08

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