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Subthreshold Voltage Noise Due to Channel Fluctuations in Active Neuronal Membranes

Steinmetz, Peter N. and Manwani, Amit and Koch, Christof and London, Michael and Segev, Idan (2000) Subthreshold Voltage Noise Due to Channel Fluctuations in Active Neuronal Membranes. Journal of Computational Neuroscience, 9 (2). pp. 133-148. ISSN 0929-5313. doi:10.1023/A:1008967807741.

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Voltage-gated ion channels in neuronal membranes fluctuate randomly between different conformational states due to thermal agitation. Fluctuations between conducting and nonconducting states give rise to noisy membrane currents and subthreshold voltage fluctuations and may contribute to variability in spike timing. Here we study subthreshold voltage fluctuations due to active voltage-gated Na+ and K+ channels as predicted by two commonly used kinetic schemes: the Mainen et al. (1995) (MJHS) kinetic scheme, which has been used to model dendritic channels in cortical neurons, and the classical Hodgkin-Huxley (1952) (HH) kinetic scheme for the squid giant axon. We compute the magnitudes, amplitude distributions, and power spectral densities of the voltage noise in isopotential membrane patches predicted by these kinetic schemes. For both schemes, noise magnitudes increase rapidly with depolarization from rest. Noise is larger for smaller patch areas but is smaller for increased model temperatures. We contrast the results from Monte Carlo simulations of the stochastic nonlinear kinetic schemes with analytical, closed-form expressions derived using passive and quasi-active linear approximations to the kinetic schemes. For all subthreshold voltage ranges, the quasi-active linearized approximation is accurate within 8% and may thus be used in large-scale simulations of realistic neuronal geometries.

Item Type:Article
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URLURL TypeDescription ReadCube access
Koch, Christof0000-0001-6482-8067
Additional Information:© 2000 Kluwer Academic Publishers. Received June 28, 1999; Revised November 9, 1999; Accepted November 19, 1999. This work was funded by NSF, NIMH, and the Sloan Center for Theoretical Neuroscience to C.K. and by the Israeli Academy of Science and the ONR to I.S. We would like to thank our collaborators Elad Schneidman and Yosef Yarom for their invaluable suggestions.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
National Institute of Mental Health (NIMH)UNSPECIFIED
Sloan Center for Theoretical NeuroscienceUNSPECIFIED
Israeli Academy of ScienceUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Subject Keywords:membrane noise, active ion channels, Markov kinetic models, stochastic ion channels
Issue or Number:2
Record Number:CaltechAUTHORS:20130816-103229674
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Official Citation:Steinmetz, P.N., Manwani, A., Koch, C. et al. J Comput Neurosci (2000) 9: 133.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40520
Deposited By: KLAB Import
Deposited On:11 Jan 2008 20:00
Last Modified:09 Nov 2021 23:49

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