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The baboon endogenous virus genome. II. Provirus sequence variations in baboon cell DNA

Cohen, Maurice and Davidson, Norman and Gilden, Raymond V. and McAllister, Robert M. and Nicolson, Margery O. and Stephens, Robert M. (1980) The baboon endogenous virus genome. II. Provirus sequence variations in baboon cell DNA. Nucleic Acids Research, 8 (19). pp. 4423-4440. ISSN 0305-1048.

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Restriction analysis of the approximately 100 integrated baboon endogenous virus (BaEV) proviruses in baboon cells and tissues has revealed two major sequence variations, both in the gag gene region of the genome. One, a 150 nucleotide pair insert, is present in a small proportion of the proviral DNAs of some baboons, but is present in the majority of the proviral DNAs of other baboons. The second, a Bam HI recognition sequence located 2.25 kb from the proviral 5' end, is missing or modified in approximately one-half of the integrated genomes. We consider the possibility that accumulation of proviruses not containing the 0.15 kb insert is correlated with viral activation and expression since it is this form that is a replication intermediate in freshly infected permissive cells. It is evident from these initial studies that the organization of the multiple BaEV proviruses in baboon DNA has undergone modification during evolution.

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Additional Information:Copyright © 1980 Oxford University Press. Received July 11, 1980. This work was supported by Contract N01-CO-75380 with the National Cancer Institute, Bethesda, Maryland 20205. We wish to thank Dr. Howard Young for a critical reading of this manuscript.
Issue or Number:19
Record Number:CaltechAUTHORS:COHnar80
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4061
Deposited By: Tony Diaz
Deposited On:26 Jul 2006
Last Modified:02 Oct 2019 23:09

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