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Microfluidic confinement of single cells of bacteria in small volumes initiates high density behavior of quorum sensing and growth and reveals its variability

Boedicker, James Q. and Vincent, Meghan E. and Ismagilov, Rustem F. (2009) Microfluidic confinement of single cells of bacteria in small volumes initiates high density behavior of quorum sensing and growth and reveals its variability. Angewandte Chemie International Edition, 48 (32). pp. 5908-5911. ISSN 1433-7851. https://resolver.caltech.edu/CaltechAUTHORS:20130821-160716355

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Abstract

One is a quorum: As few as one to three cells of Pseudomonas aeruginosa bacteria are confined in small volumes by the use of microfluidics. These small numbers of cells are able to activate quorum sensing (QS) pathways and achieve QS-dependent growth. The results also show that at low numbers of cells, initiation of QS is highly variable within a clonal population.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org./10.1002/anie.200901550DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.200901550/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748941/PubMed CentralArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.200901550/suppinfoPublisherSupporting Information
ORCID:
AuthorORCID
Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:Copyright © 2009 WILEY-VCH. Issue published online: 22 JUL 2009. Article first published online: 29 JUN 2009. Manuscript Received: 21 MAR 2009. This research was supported by the NIH Director’s Pioneer Award DP1 OD003584 to R.F.I. We thank S. Molin for generously providing the reporter strain, J. Shapiro and O. Zaborina for helpful discussion, and E. B. Haney for contributions to writing this manuscript.
Funders:
Funding AgencyGrant Number
NIH Director’s Pioneer Award1DP1 OD003584
Issue or Number:32
Record Number:CaltechAUTHORS:20130821-160716355
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130821-160716355
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40779
Collection:CaltechAUTHORS
Deposited By: Whitney Barlow
Deposited On:26 Aug 2013 22:24
Last Modified:03 Oct 2019 05:42

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