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Microfluidic Systems for Chemical Kinetics that Rely on Chaotic Mixing in Droplets

Bringer, Michelle R. and Gerdts, Cory J. and Song, Helen and Tice, Joshua D. and Ismagilov, Rustem F. (2004) Microfluidic Systems for Chemical Kinetics that Rely on Chaotic Mixing in Droplets. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 362 (1818). pp. 1087-1104. ISSN 1364-503X. doi:10.1098/rsta.2003.1364.

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This paper reviews work on a microfluidic system that relies on chaotic advection to rapidly mix multiple reagents isolated in droplets (plugs). Using a combination of turns and straight sections, winding microfluidic channels create unsteady fluid flows that rapidly mix the multiple reagents contained within plugs. The scaling of mixing for a range of channel widths, flow velocities and diffusion coefficients has been investigated. Due to rapid mixing, low sample consumption and transport of reagents with no dispersion, the system is particularly appropriate for chemical kinetics and biochemical assays. The mixing occurs by chaotic advection and is rapid (sub-millisecond), allowing for an accurate description of fast reaction kinetics. In addition, mixing has been characterized and explicitly incorporated into the kinetic model.

Item Type:Article
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URLURL TypeDescription CentralArticle
Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:Copyright © The Royal Society 2004. Published online 18 March 2004. This work was supported by the NIH (R01 EB001903), ONR Young Investigator Award (N00014- 03-10482), the Beckman foundation, the Camille and Henry Dreyfus New Faculty Award, the Research Innovation Award from Research Corporation and the Chicago MRSEC funded by the NSF. At The University of Chicago work was performed at the microfluidic facility of the Chicago MRSEC and at the Cancer Center DLMF. Photolithography was performed at MAL of the UIC by H.S.
Funding AgencyGrant Number
NIBIBR01 EB001903
Arnold and Mabel Beckman FoundationUNSPECIFIED
Camille and Henry Dreyfus FoundationUNSPECIFIED
Research Innovation Award from Research CorporationUNSPECIFIED
Subject Keywords:microfluidics; mixing; chaotic advection; droplet; kinetics; multiphase flow
Issue or Number:1818
Record Number:CaltechAUTHORS:20130821-160716511
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40780
Deposited By: Whitney Barlow
Deposited On:28 Aug 2013 19:57
Last Modified:10 Nov 2021 00:08

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