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Can we build synthetic, multicellular systems by controlling developmental signaling in space and time?

Ismagilov, Rustem F. and Maharbiz, Michel M. (2007) Can we build synthetic, multicellular systems by controlling developmental signaling in space and time? Current Opinion in Chemical Biology, 11 (6). pp. 604-611. ISSN 1367-5931. doi:10.1016/j.cbpa.2007.10.003.

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Using biological machinery to make new, functional molecules is an exciting area in chemical biology. Complex molecules containing both ‘natural’ and ‘unnatural’ components are made by processes ranging from enzymatic catalysis to the combination of molecular biology with chemical tools. Here, we discuss applying this approach to the next level of biological complexity — building synthetic, functional biotic systems by manipulating biological machinery responsible for development of multicellular organisms. We describe recent advances enabling this approach, including first, recent developmental biology progress unraveling the pathways and molecules involved in development and pattern formation; second, emergence of microfluidic tools for delivering stimuli to a developing organism with exceptional control in space and time; third, the development of molecular and synthetic biology toolsets for redesigning or de novo engineering of signaling networks; and fourth, biological systems that are especially amendable to this approach.

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Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:Copyright © 2007 Elsevier. Available online 19 November 2007. The work described in this review has been supported by National Science Foundation, the National Institutes of Health and the Keck Foundation. We thank our colleagues who have contributed to some of the work described here. We thank Tushar Bansal, Emory Chan, William Holtz, and Elena Lucchetta for helpful discussion. We thank Jessica M Price for contributions in editing and writing this manuscript.
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W. M. Keck FoundationUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20130821-160719738
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40799
Deposited By: Whitney Barlow
Deposited On:27 Aug 2013 21:52
Last Modified:10 Nov 2021 00:08

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