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Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen

Kreutz, Jason E. and Shukhaev, Anton and Du, Wenbin and Druskin, Sasha and Daugulis, Olafs and Ismagilov, Rustem F. (2010) Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen. Journal of the American Chemical Society, 132 (9). pp. 3128-3132. ISSN 0002-7863. PMCID PMC2861856. https://resolver.caltech.edu/CaltechAUTHORS:20130821-160722961

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Abstract

This paper uses microfluidics to implement genetic algorithms (GA) to discover new homogeneous catalysts using the oxidation of methane by molecular oxygen as a model system. The parameters of the GA were the catalyst, a cocatalyst capable of using molecular oxygen as the terminal oxidant, and ligands that could tune the catalytic system. The GA required running hundreds of reactions to discover and optimize catalyst systems of high fitness, and microfluidics enabled these numerous reactions to be run in parallel. The small scale and volumes of microfluidics offer significant safety benefits. The microfluidic system included methods to form diverse arrays of plugs containing catalysts, introduce gaseous reagents at high pressure, run reactions in parallel, and detect catalyst activity using an in situ indicator system. Platinum(II) was identified as an active catalyst, and iron(II) and the polyoxometalate H5PMo10V2O40 (POM-V2) were identified as active cocatalysts. The Pt/Fe system was further optimized and characterized using NMR experiments. After optimization, turnover numbers of approximately 50 were achieved with approximately equal production of methanol and formic acid. The Pt/Fe system demonstrated the compatibility of iron with the entire catalytic cycle. This approach of GA-guided evolution has the potential to accelerate discovery in catalysis and other areas where exploration of chemical space is essential, including optimization of materials for hydrogen storage and CO2 capture and modifications.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ja909853xDOIArticle
https://pubs.acs.org/doi/suppl/10.1021/ja909853xPublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861856PubMed CentralArticle
ORCID:
AuthorORCID
Du, Wenbin0000-0002-7401-1410
Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:© 2010 American Chemical Society. Published In Issue: March 10, 2010. Article ASAP: February 11, 2010. Received: November 20, 2009. This work was supported by NIH T32 GM008720 (J.E.K.), the NSF CRC CHE-0526693, and the Camille Dreyfus Teacher-Scholar Awards Program (S.D.). O.D. is grateful to the Welch Foundation (Grant No. E-1571), A.P. Sloan Foundation, and Camille and Henry Dreyfus foundation for supporting this research. We thank Elizabeth B. Haney and Heidi Park for contributions to writing and editing this manuscript.
Funders:
Funding AgencyGrant Number
NIH Predoctoral FellowshipT32 GM008720
NSFCHE-0526693
Camille and Henry Dreyfus FoundationUNSPECIFIED
Welch FoundationE-1571
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:9
PubMed Central ID:PMC2861856
Record Number:CaltechAUTHORS:20130821-160722961
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130821-160722961
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40818
Collection:CaltechAUTHORS
Deposited By: Whitney Barlow
Deposited On:23 Aug 2013 23:14
Last Modified:05 Mar 2020 15:43

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