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Dead-end filling of SlipChip evaluated theoretically and experimentally as a function of the surface chemistry and the gap size between the plates for lubricated and dry SlipChips

Li, Liang and Karymov, Mikhail A. and Nichols, Kevin P. and Ismagilov, Rustem F. (2010) Dead-end filling of SlipChip evaluated theoretically and experimentally as a function of the surface chemistry and the gap size between the plates for lubricated and dry SlipChips. Langmuir, 26 (14). pp. 12465-12471. ISSN 0743-7463.

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In this paper, we describe a method to load a microfluidic device, the SlipChip, via dead-end filling. In dead-end filling, the lubricating fluid that fills the SlipChip after assembly is dissipated through the gap between the two plates of the SlipChip instead of flowing through an outlet at the end of the fluidic path. We describe a theoretical model and associated predictions of dead-end filling that takes into consideration the interfacial properties and the gap size between plates of SlipChips. In this method, filling is controlled by the balance of pressures: for filling to occur without leaking, the inlet pressure must be greater than the capillary pressure but less than the maximum sealing pressure. We evaluated our prediction with experiments, and our empirical results agreed well with theory. Internal reservoirs were designed to prevent evaporation during loading of multiple solutions. Solutions were first loaded one at a time into inlet reservoirs; by applying a single pressure source to the device, we were able to fill multiple fluidic paths simultaneously. We used this method to fill both lubricated and dry SlipChips. Dry-loaded SlipChips were fabricated from fluorinated ethylene propylene (FEP) by using hot embossing techniques, and were successfully filled and slipped to perform a simple chemical reaction. The SlipChip design was also modified to enable ease of filling by using multiple access holes to the inlet reservoir.

Item Type:Article
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URLURL TypeDescription
http://dx.doiorg/10.1021/la101460zDOIArticle Information CentralArticle
Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:Copyright © 2010 American Chemical Society. Published In Issue: July 20, 2010. Article ASAP: June 24, 2010. Received: April 13, 2010. Revised: June 10, 2010. This work was supported by the NIH Protein Structure Initiative Specialized Centers Grant GM074961 (ATCG3D) and the NIH Director’s Pioneer Award Program, part of the NIH Roadmap for Medical Research (1 DP1 OD003584). Part of this work was performed at the Materials Research Science and Engineering Centers microfluidic facility (funded by the National Science Foundation). We thank Heidi Park for contributions to writing and editing this manuscript. Supporting Information Additional Experimental Section, tables, and figures and supporting movie. This material is available free of charge via the Internet at
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NIH Director’s Pioneer Award1DP1 OD003584
Record Number:CaltechAUTHORS:20130821-160723920
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Official Citation:Dead-End Filling of SlipChip Evaluated Theoretically and Experimentally as a Function of the Surface Chemistry and the Gap Size between the Plates for Lubricated and Dry SlipChips Liang Li, Mikhail A. Karymov, Kevin P. Nichols, and Rustem F. Ismagilov Langmuir 2010 26 (14), 12465-12471
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40824
Deposited By: Whitney Barlow
Deposited On:26 Aug 2013 17:57
Last Modified:23 Mar 2015 21:33

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