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Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System

Runyon, Matthew K. and Johnson-Kerner, Bethany L. and Ismagilov, Rustem F. (2004) Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System. Angewandte Chemie International Edition, 43 (12). pp. 1531-1536. ISSN 1433-7851. doi:10.1002/anie.200353428.

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The proof of the model is in the function: A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.

Item Type:Article
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Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:Copyright © 2004 WILEY-VCH. Issue published online: 9 MAR 2004. Article first published online: 24 FEB 2004. Manuscript Received: 28 NOV 2003. This work was supported by NSF CAREER Award, Office of Naval Research Young Investigator Award (N00014-03-10482), Searle Scholars Program, and by Dreyfus New Faculty Award. We thank Professors G. M. Whitesides, C. Chen, C. Hall, T. Van Ha, V. Turitto, and M. LaBarbera for invaluable suggestions.
Funding AgencyGrant Number
Searle Scholars ProgramUNSPECIFIED
Camille and Henry Dreyfus FoundationUNSPECIFIED
Subject Keywords:autocatalysis; biomimetic synthesis; hemostasis; microfluidic systems; self-repairing systems
Issue or Number:12
Record Number:CaltechAUTHORS:20130821-160729811
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40859
Deposited By: Whitney Barlow
Deposited On:28 Aug 2013 20:07
Last Modified:10 Nov 2021 00:09

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