Runyon, Matthew K. and Johnson-Kerner, Bethany L. and Ismagilov, Rustem F. (2004) Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System. Angewandte Chemie International Edition, 43 (12). pp. 1531-1536. ISSN 1433-7851. doi:10.1002/anie.200353428. https://resolver.caltech.edu/CaltechAUTHORS:20130821-160729811
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20130821-160729811
Abstract
The proof of the model is in the function: A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.
| Item Type: | Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Related URLs: |
| ||||||||||
| ORCID: |
| ||||||||||
| Additional Information: | Copyright © 2004 WILEY-VCH. Issue published online: 9 MAR 2004. Article first published online: 24 FEB 2004. Manuscript Received: 28 NOV 2003. This work was supported by NSF CAREER Award, Office of Naval Research Young Investigator Award (N00014-03-10482), Searle Scholars Program, and by Dreyfus New Faculty Award. We thank Professors G. M. Whitesides, C. Chen, C. Hall, T. Van Ha, V. Turitto, and M. LaBarbera for invaluable suggestions. | ||||||||||
| Funders: |
| ||||||||||
| Subject Keywords: | autocatalysis; biomimetic synthesis; hemostasis; microfluidic systems; self-repairing systems | ||||||||||
| Issue or Number: | 12 | ||||||||||
| DOI: | 10.1002/anie.200353428 | ||||||||||
| Record Number: | CaltechAUTHORS:20130821-160729811 | ||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20130821-160729811 | ||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 40859 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | Whitney Barlow | ||||||||||
| Deposited On: | 28 Aug 2013 20:07 | ||||||||||
| Last Modified: | 10 Nov 2021 00:09 |
Repository Staff Only: item control page
