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Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System

Runyon, Matthew K. and Johnson-Kerner, Bethany L. and Ismagilov, Rustem F. (2004) Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System. Angewandte Chemie International Edition, 43 (12). pp. 1531-1536. ISSN 1433-7851. doi:10.1002/anie.200353428. https://resolver.caltech.edu/CaltechAUTHORS:20130821-160729811

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Abstract

The proof of the model is in the function: A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/anie.200353428DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.200353428/abstract?PublisherArticle
ORCID:
AuthorORCID
Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:Copyright © 2004 WILEY-VCH. Issue published online: 9 MAR 2004. Article first published online: 24 FEB 2004. Manuscript Received: 28 NOV 2003. This work was supported by NSF CAREER Award, Office of Naval Research Young Investigator Award (N00014-03-10482), Searle Scholars Program, and by Dreyfus New Faculty Award. We thank Professors G. M. Whitesides, C. Chen, C. Hall, T. Van Ha, V. Turitto, and M. LaBarbera for invaluable suggestions.
Funders:
Funding AgencyGrant Number
NSF CAREERUNSPECIFIED
ONRN00014-03-10482
Searle Scholars ProgramUNSPECIFIED
Camille and Henry Dreyfus FoundationUNSPECIFIED
Subject Keywords:autocatalysis; biomimetic synthesis; hemostasis; microfluidic systems; self-repairing systems
Issue or Number:12
DOI:10.1002/anie.200353428
Record Number:CaltechAUTHORS:20130821-160729811
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130821-160729811
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40859
Collection:CaltechAUTHORS
Deposited By: Whitney Barlow
Deposited On:28 Aug 2013 20:07
Last Modified:10 Nov 2021 00:09

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