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A Microfluidic System for Controlling Reaction Networks in Time

Song, Helen and Tice, Joshua D. and Ismagilov, Rustem F. (2003) A Microfluidic System for Controlling Reaction Networks in Time. Angewandte Chemie International Edition, 42 (7). pp. 768-772. ISSN 1433-7851. doi:10.1002/anie.200390203.

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Millisecond mixing and transport with no dispersion are achieved by unsteady flows induced in droplets of about 60 pL that travel through winding microfluidic channels (top). Fluorescence can be used to monitor mixing (bottom) or measure reaction rates. In principle, arbitrarily complex reaction networks can be created by combining and splitting streams of such droplets.

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Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:© 2002 WILEY-VCH. Issue published online: 17 FEB 2003. Article first published online: 17 FEB 2003. Manuscript Received: 6 SEP 2002. This work was supported by the Camille and Henry Dreyfus New Faculty Award Program, the Searle Scholars Program, an award from Research Corporation, the Chicago MRSEC funded by the NSF. H.S. was supported by a Predoctoral Training Grant of the NIH (GM 08720). We thank our colleagues at the University of Chicago for invaluable discussions and suggestions. We thank Prof. Sidney Nagel, in addition, for an equipment loan and Ian Hawkins for measuring surface tensions. Photolithography was performed by H.S. at MAL of the University of Illinois at Chicago. Microscopy was conducted at the University of Chicago Cancer Center Digital Light Microscopy Facility.
Funding AgencyGrant Number
Camille and Henry Dreyfus FoundationUNSPECIFIED
Searle Scholars ProgramUNSPECIFIED
Research CorporationUNSPECIFIED
NIHGM 08720
Subject Keywords:analytical methods; kinetics; microfluidics; microreactors; reaction networks cavity flows; scaling laws; microchannels; device; operations; pressure
Issue or Number:7
Record Number:CaltechAUTHORS:20130821-160732735
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40874
Deposited By: Whitney Barlow
Deposited On:28 Aug 2013 21:32
Last Modified:10 Nov 2021 04:23

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