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Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers

Tice, Joshua D. and Song, Helen and Lyon, Adam D. and Ismagilov, Rustem F. (2003) Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers. Langmuir, 19 (22). pp. 9127-9133. ISSN 0743-7463. doi:10.1021/la030090w.

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This paper reports an experimental characterization of a simple method for rapid formation of droplets, or plugs, of multiple aqueous reagents without bringing reagents into contact prior to mixing. Droplet-based microfluidics offers a simple method of achieving rapid mixing and transport with no dispersion. In addition, this paper shows that organic dyes at high concentrations should not be used for the visualization of flow patterns and mixing of aqueous plugs in multiphase flows in this system (fluorinated carrier fluid and PDMS microchannels). It reports an inorganic dye that can be used instead. This work focuses on mixing in plugs moving through straight channels. It demonstrates that, when traveling through straight microchannels, mixing within plugs by steady recirculating flow is highly sensitive to the initial distribution of the aqueous reagents established by the eddy flow at the tip of the forming plug (twirling). The results also show how plugs with proper distribution of the aqueous reagents could be formed in order to achieve optimal mixing of the reagents in this system.

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Ismagilov, Rustem F.0000-0002-3680-4399
Additional Information:Copyright © 2003 American Chemical Society. Published In Issue: October 28, 2003. Received March 4, 2003. Revised June 11, 2003. This work was supported by the Camille and Henry Dreyfus New Faculty Award, the Research Innovation Award from Research Corporation, by Chicago MRSEC funded by NSF, and by the Predoctoral Training Grant (H.S.) of the NIH (GM 08720). This work has been performed at the Chicago MRSEC microfluidics facility. Photolithography was performed at MAL of UIC. We thank Professors Sidney R. Nagel and Thomas A. Witten for helpful discussions on the subjects of the Capillary number and the mechanisms of eddy formation.
Funding AgencyGrant Number
Camille and Henry Dreyfus FoundationUNSPECIFIED
Research Innovation Award from Research CorporationUNSPECIFIED
NIHGM 08720
Subject Keywords:total analysis systems; surface-tension; image-analysis; scaling laws; flow; microchannels; poly(dimethylsiloxane); device; proteomics; technology
Issue or Number:22
Record Number:CaltechAUTHORS:20130821-160734086
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40882
Deposited By: Whitney Barlow
Deposited On:28 Aug 2013 21:47
Last Modified:10 Nov 2021 04:23

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