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Insights into neural crest development and evolution from genomic analysis

Simões-Costa, Marcos and Bronner, Marianne E. (2013) Insights into neural crest development and evolution from genomic analysis. Genome Research, 23 (7). pp. 1069-1080. ISSN 1088-9051. PMCID PMC3698500. doi:10.1101/gr.157586.113.

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The neural crest is an excellent model system for the study of cell type diversification during embryonic development due to its multipotency, motility, and ability to form a broad array of derivatives ranging from neurons and glia, to cartilage, bone, and melanocytes. As a uniquely vertebrate cell population, it also offers important clues regarding vertebrate origins. In the past 30 yr, introduction of recombinant DNA technology has facilitated the dissection of the genetic program controlling neural crest development and has provided important insights into gene regulatory mechanisms underlying cell migration and differentiation. More recently, new genomic approaches have provided a platform and tools that are changing the depth and breadth of our understanding of neural crest development at a "systems" level. Such advances provide an insightful view of the regulatory landscape of neural crest cells and offer a new perspective on developmental as well as stem cell and cancer biology.

Item Type:Article
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URLURL TypeDescription CentralArticle
Simões-Costa, Marcos0000-0003-1452-7068
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2013 Published by Cold Spring Harbor Laboratory Press. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at We would like to thank Tatiana Hochgreb, Sujata Bhattacharyya, and Stephen Green for critical reading of the manuscript and helpful suggestions. This work was supported by NIH grants HD037105 and DE16459 (M.E.B.), the Pew Fellows Program in the Biomedical Sciences (M.S-C.), and a Caltech Cell Center fellowship (M.S-C.)
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Pew Fellows Program in the Biomedical SciencesUNSPECIFIED
Caltech Cell Center fellowshipUNSPECIFIED
Issue or Number:7
PubMed Central ID:PMC3698500
Record Number:CaltechAUTHORS:20130827-110646016
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40957
Deposited By: John Wade
Deposited On:27 Aug 2013 18:30
Last Modified:10 Nov 2021 04:24

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