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A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Reimann, Michael W. and Anastassiou, Costas A. and Perin, Rodrigo and Hill, Sean L. and Markram, Henry and Koch, Christof (2013) A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents. Neuron, 79 (2). pp. 375-390. ISSN 0896-6273. PMCID PMC3732581. https://resolver.caltech.edu/CaltechAUTHORS:20130903-094008150

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Abstract

Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but neither the detailed biophysical knowledge nor the required computational power have been available to model these processes. We simulated the LFP in a model of the rodent neocortical column composed of >12,000 reconstructed, multicompartmental, and spiking cortical layer 4 and 5 pyramidal neurons and basket cells, including five million dendritic and somatic compartments with voltage- and ion-dependent currents, realistic connectivity, and probabilistic AMPA, NMDA, and GABA synapses. We found that, depending on a number of factors, the LFP reflects local and cross-layer processing. Active currents dominate the generation of LFPs, not synaptic ones. Spike-related currents impact the LFP not only at higher frequencies but below 50 Hz. This work calls for re-evaluating the genesis of LFPs.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.neuron.2013.05.023DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732581PubMed CentralArticle
ORCID:
AuthorORCID
Anastassiou, Costas A.0000-0002-6793-0611
Koch, Christof0000-0001-6482-8067
Additional Information:© 2013 Elsevier Under an Elsevier user license. Accepted: May 16, 2013; Published: July 24, 2013. This work was supported by the National Institute of Neurological Disorders and Stroke, Human Frontier Science Program, Swiss National Science Foundation, the Allen Institute for Brain Science, and the Mathers Charitable Foundation and by funding to the Blue Brain Project by the ETH Board and EPFL. Financial support for the CADMOS Blue Gene/P system was provided by the Canton of Geneva, Canton of Vaud, Hans Wilsdorf Foundation, Louis-Jeantet Foundation, University of Geneva, University of Lausanne, and EPFL. Special thanks goes to G. Buzsáki, E. Schomburg, A. Shai, Y. Billeh, J. Taxidis, and members of the Blue Brain Consortium, in particular, Michael Hines, James King, Eilif Muller, Srikant Ramaswamy, Felix Schürmann, and Werner van Geit.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Swiss National Science Foundation (SNSF)UNSPECIFIED
Allen Institute for Brain ScienceUNSPECIFIED
G. Harold & Leila Y. Mathers FoundationUNSPECIFIED
ETH BoardUNSPECIFIED
École Polytechnique Fédérale de Lausanne (EPFL)UNSPECIFIED
Canton of GenevaUNSPECIFIED
Canton of VaudUNSPECIFIED
Hans Wilsdorf FoundationUNSPECIFIED
Louis-Jeantet FoundationUNSPECIFIED
University of GenevaUNSPECIFIED
University of LausanneUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC3732581
Record Number:CaltechAUTHORS:20130903-094008150
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130903-094008150
Official Citation:Michael W. Reimann, Costas A. Anastassiou, Rodrigo Perin, Sean L. Hill, Henry Markram, Christof Koch, A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents, Neuron, Volume 79, Issue 2, 24 July 2013, Pages 375-390, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2013.05.023. (http://www.sciencedirect.com/science/article/pii/S0896627313004431)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41046
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Sep 2013 21:59
Last Modified:02 Jul 2020 19:59

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