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Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research

Wei, Wei and Shin, Young Shik and Ma, Chao and Wang, Jun and Elitas, Meltem and Fan, Rong and Heath, James R. (2013) Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research. Genome Medicine, 5 . Art. No. 75. ISSN 1756-994X. PMCID PMC3978720. https://resolver.caltech.edu/CaltechAUTHORS:20130906-082857317

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Abstract

Single-cell functional proteomics assays can connect genomic information to biological function through quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years and are providing approaches for directly elucidating phosphoprotein signaling networks in cancer cells or for capturing high-resolution snapshots of immune system function in patients with various disease conditions. We discuss advances in single-cell proteomics platforms, with an emphasis on microchip methods. These methods can provide a direct correlation of morphological, functional and molecular signatures at the single-cell level. We also provide examples of how those platforms are being applied to both fundamental biology and clinical studies, focusing on immune-system monitoring and phosphoprotein signaling networks in cancer.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://genomemedicine.com/content/5/8/75PublisherArticle
http://dx.doi.org/10.1186/gm479DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978720/PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:© 2013 BioMed Central Ltd. Published: 29 August 2013. Some of the work reviewed here was supported by the National Cancer Institute (5U54 CA119347 and R01 CA170689-01 to JRH) and the National Institutes of Health (NIH 1 U01 CA164252-01 to RF and U54 CA143798 to RF).
Funders:
Funding AgencyGrant Number
NIH5U54 CA119347
NIHR01 CA170689-01
NIH1 U01 CA164252-01
NIHU54 CA143798
National Cancer InstituteUNSPECIFIED
PubMed Central ID:PMC3978720
Record Number:CaltechAUTHORS:20130906-082857317
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130906-082857317
Official Citation:Wei W, et al.: Microchip platforms for multiplex singlecell functional proteomics with applications to immunology and cancer research. Genome Medicine 2013, 5:75
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41134
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Sep 2013 21:40
Last Modified:03 Oct 2019 05:46

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