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Role of Vortices in Growth of Microbubbles at Mitral Mechanical Heart Valve Closure

Rambod, Edmond and Beizai, Masoud and Sahn, David J. and Gharib, Morteza (2007) Role of Vortices in Growth of Microbubbles at Mitral Mechanical Heart Valve Closure. Annals of Biomedical Engineering, 35 (7). pp. 1131-1145. ISSN 0090-6964. https://resolver.caltech.edu/CaltechAUTHORS:20130910-151007352

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Abstract

This study is aimed at refining our understanding of the role of vortex formation at mitral mechanical heart valve (MHV) closure and its association with the high intensity transient signals (HITS) seen in echocardiographic studies with MHV recipients. Previously reported numerical results described a twofold process leading to formation of gas-filled microbubbles in-vitro: (1) nucleation and (2) growth of micron size bubbles. The growth itself consists of two processes: (a) diffusion and (b) sudden pressure drop due to valve closure. The role of diffusion has already been shown to govern the initial growth of nuclei. Pressure drop at mitral MHV closure may be attributed to other phenomena such as squeezed flow, water hammer and primarily, vortex cavitation. Mathematical analysis of vortex formation at mitral MHV closure revealed that a closing velocity of approximately 12 m/s can induce a strong regurgitant vortex which in return can instigate a local pressure drop of about 0.9 atm. A 2D experimental model of regurgitant flows was used to substantiate the impact of vortices. At simulated flow and pressure conditions, a regurgitant vortex was observed to drastically enlarge micron size hydrogen bubbles at its core.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s10439-007-9293-y DOIArticle
http://link.springer.com/article/10.1007%2Fs10439-007-9293-yPublisherArticle
Additional Information:© 2007 Biomedical Engineering Society. Received 23 June 2006; accepted 5 March 2007; published online 3 April 2007.
Group:GALCIT
Subject Keywords:Mechanical heart valves, HITS, Cavitation, Nucleation, Microbubble growth, Vortex formation
Issue or Number:7
Record Number:CaltechAUTHORS:20130910-151007352
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130910-151007352
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41220
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Sep 2013 21:46
Last Modified:03 Oct 2019 05:46

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