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The Embryonic Vertebrate Heart Tube Is a Dynamic Suction Pump

Forouhar, Arian S. and Liebling, Michael and Hickerson, Anna and Nasiraei-Moghaddam, Abbas and Tsai, Huai-Jen and Hove, Jay R. and Fraser, Scott E. and Dickinson, Mary E. and Gharib, Morteza (2006) The Embryonic Vertebrate Heart Tube Is a Dynamic Suction Pump. Science, 312 (5774). pp. 751-753. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20130911-075435084

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Abstract

The embryonic vertebrate heart begins pumping blood long before the development of discernable chambers and valves. At these early stages, the heart tube has been described as a peristaltic pump. Recent advances in confocal laser scanning microscopy and four-dimensional visualization have warranted another look at early cardiac structure and function. We examined the movement of cells in the embryonic zebrafish heart tube and the flow of blood through the heart and obtained results that contradict peristalsis as a pumping mechanism in the embryonic heart. We propose a more likely explanation of early cardiac dynamics in which the pumping action results from suction due to elastic wave propagation in the heart tube.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1123775 DOIArticle
http://www.sciencemag.org/content/312/5774/751PublisherArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5377-0223
Gharib, Morteza0000-0002-2204-9302
Additional Information:© 2006 American Association for the Advancement of Science. Received 13 December 2005; accepted 6 April 2006. We thank J. Dabiri, M. Milano, J. Vermot, and J. Pierce for comments on the paper; S. Megason and L. Trinh for help with zebrafish and imaging techniques; and S. Lin for providing the Tg(gata1:GFP) zebrafish line. This work was supported by American Heart Association grant 03665071Y (J.R.H.), NIH grant 5R01HL078694 (S.E.F., M.E.D., and M.L.), and Swiss National Science Foundation grants PBEL2-104418 and PA002-111433 (M.L.).
Group:GALCIT
Funders:
Funding AgencyGrant Number
American Heart Association03665071Y
NIH5R01HL078694
Swiss National Science Foundation (SNSF)PBEL2-104418
Swiss National Science Foundation (SNSF)PA002-111433
Issue or Number:5774
Record Number:CaltechAUTHORS:20130911-075435084
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130911-075435084
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41227
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Sep 2013 22:02
Last Modified:03 Oct 2019 05:47

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