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Structure function interface with sequential shortening of basal and apical components of the myocardial band

Castella, Manuel and Buckberg, Gerald D. and Saleh, Saleh and Gharib, Morteza (2005) Structure function interface with sequential shortening of basal and apical components of the myocardial band. European Journal of Cardio-Thoracic Surgery, 27 (6). pp. 980-987. ISSN 1010-7940. https://resolver.caltech.edu/CaltechAUTHORS:20130911-080847977

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Abstract

Objective: To mechanically test the intact cardiac structure to determine the sequence of contraction within the myocardial mass to try to explain ejection and suction. Methods: In 24 pigs (30–85kg), segment shortening at the site of sonomicrometer crystals was continuously recorded. The ECG evaluated rhythm, and Millar pressure transducers measured intraventricular pressure and dP/dt. Results: Study of segment shortening defined a sequence of contraction within the myocardial mass, starting at the free wall of the right ventricle and on the endocardial side of the antero-septal wall of the left. Crystal location defined underlying contractile trajectory; transverse in right ventricle followed by basal posterior left ventricle, and from the endocardial anterior wall to the posterior apical segment and finally to the epicardial side of the anterior wall. Mean shortening fraction averaged 18±3%, with endocardial exceeding epicardial shortening by 5±1%. Epicardial segment crystal displacement followed endocardial shortening by 82±23ms in the anterior wall, and finished 92±33ms after endocardial shortening stopped, time frame that matches the interval of fast drop of ventricular pressure and the start of suction. Conclusions: Crystal shortening fraction sequence followed the rope-like myocardial band model to contradict traditional thinking, with two starting points of excitation–contraction, the right anterior free wall of the right ventricle, and the endocardial side of the anterior wall. Active suction may be due to active shortening of the epicardial fibers of the anterior wall, because relaxation was not detected when both mitral and aortic valves were closed during the interval previously termed ‘isovolumetric relaxation’.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ejcts.2005.01.051 DOIArticle
http://ejcts.oxfordjournals.org/content/27/6/980PublisherArticle
Additional Information:© 2005 Elsevier B.V. Received 23 November 2004; accepted 20 January 2005; Available online 7 March 2005. Presented at the C. Walton Lillehei Resident Forum Session, 84th American Association for Thoracic Surgery Meeting, Toronto, April 25-28, 2004.
Group:GALCIT
Subject Keywords:Cardiac anatomy; Cardiac function; Ventricular structure; Helical heart
Issue or Number:6
Record Number:CaltechAUTHORS:20130911-080847977
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130911-080847977
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41229
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Sep 2013 22:06
Last Modified:03 Oct 2019 05:47

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