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Flow in the Early Embryonic Human Heart: A Numerical Study

DeGroff, C. G. and Thornburg, B. L. and Pentecost, J. O. and Thornburg, K. L. and Gharib, M. and Sahn, D. J. and Baptista, A. (2003) Flow in the Early Embryonic Human Heart: A Numerical Study. Pediatric Cardiology, 24 (4). pp. 375-380. ISSN 0172-0643 . https://resolver.caltech.edu/CaltechAUTHORS:20130911-100118473

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Abstract

Computational fluid dynamic (CFD) experimentation provides a unique medium for detailed examination of flow through complex embryonic heart structures. The purpose of this investigation was to demonstrate that streaming blood flow patterns exist in the early embryonic heart and that fluid surface stresses change significantly with anomalous alterations in fetal heart lumen shape. Stages 10 and 11 early human embryo hearts were digitized as calibrated two-dimensional (2D) cross-sectional sequential images. A 3D surface was constructed from the stacking of these 2D images. CFD flow solutions were obtained (steady and pulsatile flow). Particle traces were placed in the inlet and outlet portions of these two stages. Sections of the embryonic heart were artificially reshaped. CFD flow solutions were obtained and surface stress changes analyzed. Streaming was shown to exist, with particles released on one or the other side of the cardiac lumen tending not to cross over and mix with particles released from the opposite side of the cardiac lumen. Shear stress changes (stage 10) occur in the altered lumens. Streaming exists in steady and pulsatile flow scenarios in the embryonic heart models. There are differences in local shear stress distributions with surface shape anomalies of the fetal heart lumen. These observations may help shed light on the potential role of fluid dynamic factors in determining patterns of abnormal heart development.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s00246-002-0343-9DOIArticle
http://link.springer.com/article/10.1007/s00246-002-0343-9PublisherArticle
Additional Information:© 2003 Springer Verlag. Paper presented in part at the International Conference on Mechanics in Medicine and Biology, Maui, HI, USA, April 2000, and the 3rd World Congress of Pediatric Cardiology and Cardiac Surgery, Toronto, Canada, May 2001.
Group:GALCIT
Subject Keywords:computational fluid dynamics; congenital heart disease; embryology fetal heart
Issue or Number:4
Record Number:CaltechAUTHORS:20130911-100118473
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130911-100118473
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41240
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Sep 2013 22:35
Last Modified:03 Oct 2019 05:47

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