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Microbubbles and mitral valve prostheses — transesophageal echocardiographic evaluation

Levy, Denis J. and Child, John S. and Rambod, Edmond and Gharib, Morteza and Milo, Simcha and Reisner, Shimon A. (1999) Microbubbles and mitral valve prostheses — transesophageal echocardiographic evaluation. European Journal of Ultrasound, 10 (1). pp. 31-40. ISSN 0929-8266. doi:10.1016/s0929-8266(99)00041-5.

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Objective: To assess whether microbubbles are associated with a specific type of mitral valve prosthesis and to investigate the relationship of microbubbles to ventricular function and mitral regurgitation. One of the types of spontaneous echocardiographic contrast observed in patients with prosthetic heart valves has been described as microbubbles. Methods: Clinical data and videotapes of patients with a prosthetic mitral valve who had undergone transesophageal echocardiography at the UCLA Medical Center between May 1989 and February 1995 were retrospectively reviewed. There were 109 studies (74 patients) available for review by two independent observers. Results: Microbubbles occurred in 49 of the 66 studies of St. Jude valves ( 74%), eight of the 12 studies of Bjork Shiley valves (67%), four of four studies of Medtronic valves (100%) and zero of 23 studies of tissue valves (0%). Patients with an estimated ejection fraction greater than 45% were found to have a much higher likelihood of having microbubbles observed. There was no statistically significant association between the degree of mitral regurgitation and the observation of microbubbles. Conclusions: Microbubbles are a common phenomenon occurring in patients with mechanical mitral prostheses compared with tissue mitral valve prostheses. Their formation depends on the systolic ventricular function, suggesting a cavitation-like phenomenon participating in their formation perhaps due to the rate or velocity of the valve closure.

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Gharib, Morteza0000-0003-0754-4193
Additional Information:© 1999 Elsevier Science Ireland Ltd. Received 23 November 1998; received in revised form 3 June 1999; accepted 7 June 1999.
Subject Keywords:Spontaneous echocardiographic contrast; Microbubbles; Prosthetic heart valves; Transesophageal echocardiography
Issue or Number:1
Record Number:CaltechAUTHORS:20130912-095252698
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Official Citation:Denis J Levy, John S Child, Edmond Rambod, Morteza Gharib, Simcha Milo, Shimon A Reisner, Microbubbles and mitral valve prostheses — transesophageal echocardiographic evaluation, European Journal of Ultrasound, Volume 10, Issue 1, September 1999, Pages 31-40, ISSN 0929-8266, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41279
Deposited By: Tony Diaz
Deposited On:12 Sep 2013 23:07
Last Modified:10 Nov 2021 04:28

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