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Commensal bacteria induce a barrier protective response to prevent sensitization to food allergens

Feehley, Taylor and Stefka, Andrew and Tripathi, Prabhanshu and McCoy, Kathy and Mazmanian, Sarkis and Seo, Goo-Young and Theriault, Betty and Antonopoulos, Dionysios and Chang, Eugene and Nagler, Cathryn (2013) Commensal bacteria induce a barrier protective response to prevent sensitization to food allergens. Journal of Immunology, 190 . 120.19. ISSN 0022-1767. https://resolver.caltech.edu/CaltechAUTHORS:20130912-102721188

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Abstract

Environmentally-induced alterations in the commensal microbiome have been implicated in the increasing prevalence of food allergy. We found that antibiotic treatment of neonatal mice leads to reduced proportions of regulatory T cells (Tregs) in the colonic lamina propria(LP), impaired production of intestinal IgA, and elevated peanut (PN) specific IgE/IgG1 in response to sensitization. Selective colonization of gnotobiotic mice linked the Treg/IgA inducing capacity to a consortium of bacteria within the Clostridia class. Introduction of either a conventional SPF microbiota or a mixture of Clostridia strains to antibiotic-treated mice restored the Treg and IgA compartments and blocked the induction of a food allergic response. Clostridia colonized gnotobiotic mice displayed increased expression of IL-23 and IL-22 in the colonic LP compartment and the induction of anti-microbial REG3β expression in the epithelium. Collectively, these results suggest that the maintenance of oral tolerance to dietary antigens relies on bacterial populations that induce a barrier protective response, which includes activation of the IL-23/IL22 axis and the expansion of intestinal Tregs and IgA secreting B cells. Our findings hold promise for the development of approaches to prevent or treat food allergy based on modulation of the composition of intestinal microbiota.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://jimmunol.org/cgi/content/meeting_abstract/190/1_MeetingAbstracts/120.19PublisherArticle
ORCID:
AuthorORCID
Mazmanian, Sarkis0000-0003-2713-1513
Additional Information:© 2013 American Association of Immunologists.
Record Number:CaltechAUTHORS:20130912-102721188
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130912-102721188
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41284
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Sep 2013 22:46
Last Modified:03 Oct 2019 05:47

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