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Generation of Selective High Affinity Ligands to Block CD81-Large Extracellular Loop: Hepatitis C Virus-E2 Glycoprotein Interaction

Al Olaby, R. R. and Balhorn, R. and Chromy, B. and Vielmitter, J. and Eldridge, A. and Hok, S. and Azzazy, H. M. (2013) Generation of Selective High Affinity Ligands to Block CD81-Large Extracellular Loop: Hepatitis C Virus-E2 Glycoprotein Interaction. Journal of Hepatology, 58 . S481-S482. ISSN 0168-8278 . https://resolver.caltech.edu/CaltechAUTHORS:20130917-085309612

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Abstract

Background and Aims: HCV infects around 3.3% of the world population. The standard of care HCV treatment (Peginterferon/Ribavirin) leads to serious side effects and SVR is <50% in genotype-1 patients. The newly FDA approved protease inhibitors (Telaprevir/Boceprevir) were found to be effective when each is combined with PR giving higher SVR rates in GT-1. However the poor safety profile of TVR and BOC reported in the Week 16 analysis of the French Early Access Program suggest there is still a need for better HCV drugs. Many companies have active programs developing HCV protease and polymerase inhibitors. We are developing drugs to block an earlier step in HCV infection, CD81 mediated invasion. In this study we are developing Selective High Affinity Ligands (SHALs) to target the E2 binding site on CD81 and block their interaction.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/S0168-8278(13)61186-1DOIArticle
Additional Information:© 2013 European Association for the Study of the Liver.
Record Number:CaltechAUTHORS:20130917-085309612
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130917-085309612
Official Citation:GENERATION OF SELECTIVE HIGH AFFINITY LIGANDS TO BLOCK CD81-LARGE EXTRACELLULAR LOOP: HEPATITIS C VIRUS–E2 GLYCOPROTEIN INTERACTION Al Olaby, R.R. et al. Journal of Hepatology , Volume 58 , S481 - S482
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41355
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Sep 2013 19:55
Last Modified:03 Oct 2019 05:48

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