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Lesion studies of human emotion and feeling

Feinstein, Justin S. (2013) Lesion studies of human emotion and feeling. Current Opinion in Neurobiology, 23 (3). pp. 304-309. ISSN 0959-4388.

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The lesion method provides unique insight into how the human brain generates emotion and feeling. Recent work has explored a number of interesting topics including the dissociation of emotional experience from memory in patients with amnesia, the reliability of specific emotional deficits following focal brain damage (including fear and the amygdala), and the investigation of compensatory neural mechanisms in lesion patients. Several detailed case studies have challenged the necessary role of the insular cortex in both awareness and feeling by showing that even in rare instances of complete bilateral insula destruction, the patient remains fully sentient and capable of expressing and feeling emotion. These findings highlight the distributed nature of emotion processing in the human brain and emphasize the importance of utilizing the lesion method for elucidating brain–behavior relationships.

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Additional Information:© 2013 Elsevier B.V. Available online 4th January 2013. I would like to thank Ralph Adolphs and René Hurlemann for their helpful comments during the preparation of this manuscript. I am especially grateful to Daniel Tranel, my mentor and teacher of the human lesion method. Finally, I would like to thank Sahib Khalsa and David Rudrauf, to whom I dedicate this paper.
Issue or Number:3
Record Number:CaltechAUTHORS:20130919-130327566
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Official Citation:Justin S Feinstein, Lesion studies of human emotion and feeling, Current Opinion in Neurobiology, Volume 23, Issue 3, June 2013, Pages 304-309, ISSN 0959-4388, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41418
Deposited By: Tony Diaz
Deposited On:19 Sep 2013 20:10
Last Modified:03 Oct 2019 05:48

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