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Structure and function relationship of human heart from DENSE MRI

Moghaddam, Abbas N. and Gharib, Morteza (2007) Structure and function relationship of human heart from DENSE MRI. In: Medical Imaging 2007: Physiology, Function, and Structure from Medical Images. Proceedings of SPIE. No.6511. Society of Photo-optical Instrumentation Engineers , Bellingham, WA, Art. No. L5111. ISBN 978-0-8194-6629-7 . http://resolver.caltech.edu/CaltechAUTHORS:20130920-101057355

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Abstract

The study here, suggests a macroscopic structure for the Left Ventricle (LV), based on the heart kinematics which is obtained through imaging. The measurement of the heart muscle deformation using the Displacement ENcoding with Stimulated Echoes (DENSE) MRI, which describes the heart kinematics in the Lagrangian frame work, is used to determine the high resolution patterns of true myocardial strain. Subsequently, the tangential Shortening Index (SI) and the thickening of the LV wall are calculated for each data point. Considering the heart as a positive-displacement pump, the contribution of each segment of LV in the heart function, can be determined by the SI and thickening of the wall in the same portion. Hence the SI isosurfaces show the extent and spatial distribution of the heart activity and reveals its macro structure. The structure and function of the heart are, therefore, related which in turn results in a macroscopic model for the LV. In particular, it was observed that the heart functionality is not uniformly distributed in the LV, and the regions with greater effect on the pumping process, form a band which wraps around the heart. These results, which are supported by the established histological evidence, may be considered as a landmark in connecting the structure and function of the heart through imaging. Furthermore, the compatibility of this model with microscopic observations about the fiber direction is investigated [1]. This method may be used for planning as well as post evaluation of the ventriculoplasty.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.711269 DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1299511PublisherArticle
Additional Information:© 2007 SPIE.
Group:GALCIT
Subject Keywords:cardiac mechanics, image-based biomechanical models, strain, structure, function, tissue deformation
Record Number:CaltechAUTHORS:20130920-101057355
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130920-101057355
Official Citation:Abbas N. Moghaddam ; Morteza Gharib; Structure and function relationship of human heart from DENSE MRI. Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65111L (March 29, 2007); doi:10.1117/12.711269
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41440
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Sep 2013 19:21
Last Modified:30 Sep 2016 17:35

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