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High carbohydrate–low protein consumption maximizes Drosophila lifespan

Bruce, Kimberley D. and Hoxha, Sany and Carvalho, Gil B. and Yamada, Ryuichi and Wang, Horng-Dar and Karayan, Paul and He, Shan and Brummel, Ted and Kapahi, Pankaj and Ja, William W. (2013) High carbohydrate–low protein consumption maximizes Drosophila lifespan. Experimental Gerontology, 48 (10). pp. 1129-1135. ISSN 0531-5565. PMCID PMC3687007. http://resolver.caltech.edu/CaltechAUTHORS:20130930-143035994

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Abstract

Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohydrates also play a central role. To clarify how nutritional factors influence longevity, nutrient consumption and lifespan were measured on a series of diets with varying yeast and sugar content. We show that optimal lifespan requires both high carbohydrate and low protein consumption, but neither nutrient by itself entirely predicts lifespan. Increased dietary carbohydrate or protein concentration does not always result in reduced feeding—the regulation of food consumption is best described by a constant daily caloric intake target. Moreover, due to differences in food intake, increased concentration of a nutrient within the diet does not necessarily result in increased consumption of that particular nutrient. Our results shed light on the issue of dietary effects on lifespan and highlight the need for accurate measures of nutrient intake in dietary manipulation studies.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.exger.2013.02.003 DOIArticle
http://www.sciencedirect.com/science/article/pii/S053155651300034XPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687007/PubMed CentralArticle
Additional Information:© Elsevier Inc. Received 20 August 2012. Received in revised form 12 December 2012. Accepted 4 February 2013. Available online 10 February 2013. Section Editor: Christiaan Leeuwenburgh. This work was supported by grants from the National Institutes of Health (1R15AG027749, T.B.; R01 AG031337 and AG038012, P.K.; and R00AG030493 and R21DK092735, W.W.J.), National Science Council (NSC 100-2311-B-007-006, H.-D.W.), The Ellison Medical Foundation (P.K. and W.W.J.), and the Glenn Foundation for Medical Research/American Federation for Aging Research (P.K. and W.W.J.).
Funders:
Funding AgencyGrant Number
NIH1R15AG027749–01A1
NIHR01 AG031337
NIHAG038012
NIHR00AG030493
NIHR21DK092735
National Science Council (Taipei)NSC 100-2311-B-007-006
Ellison Medical FoundationUNSPECIFIED
Glenn Foundation for Medical ResearchUNSPECIFIED
American Federation for Aging ResearchUNSPECIFIED
Subject Keywords:Aging; Dietary restriction; Drosophila; Feeding; Longevity; Nutrition
PubMed Central ID:PMC3687007
Record Number:CaltechAUTHORS:20130930-143035994
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130930-143035994
Official Citation:Kimberley D. Bruce, Sany Hoxha, Gil B. Carvalho, Ryuichi Yamada, Horng-Dar Wang, Paul Karayan, Shan He, Ted Brummel, Pankaj Kapahi, William W. Ja, High carbohydrate–low protein consumption maximizes Drosophila lifespan, Experimental Gerontology, Volume 48, Issue 10, October 2013, Pages 1129-1135, ISSN 0531-5565, http://dx.doi.org/10.1016/j.exger.2013.02.003. (http://www.sciencedirect.com/science/article/pii/S053155651300034X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41564
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:30 Sep 2013 21:53
Last Modified:21 Jul 2017 22:23

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