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The utility of multichannel local field potentials for brain-machine interfaces

Hwang, Eun Jung and Andersen, Richard A. (2013) The utility of multichannel local field potentials for brain-machine interfaces. Journal of Neural Engineering, 10 (4). Art. No. 046005. ISSN 1741-2560. PMCID PMC3731147. doi:10.1088/1741-2560/10/4/046005. https://resolver.caltech.edu/CaltechAUTHORS:20131001-084826145

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Abstract

Objective. Local field potentials (LFPs) that carry information about the subject's motor intention have the potential to serve as a complement or alternative to spike signals for brain–machine interfaces (BMIs). The goal of this study is to assess the utility of LFPs for BMIs by characterizing the largely unknown information coding properties of multichannel LFPs. Approach. Two monkeys were implanted, each with a 16-channel electrode array, in the parietal reach region where both LFPs and spikes are known to encode the subject's intended reach target. We examined how multichannel LFPs recorded during a reach task jointly carry reach target information, and compared the LFP performance to simultaneously recorded multichannel spikes. Main Results. LFPs yielded a higher number of channels that were informative about reach targets than spikes. Single channel LFPs provided more accurate target information than single channel spikes. However, LFPs showed significantly larger signal and noise correlations across channels than spikes. Reach target decoders performed worse when using multichannel LFPs than multichannel spikes. The underperformance of multichannel LFPs was mostly due to their larger noise correlation because noise de-correlated multichannel LFPs produced a decoding accuracy comparable to multichannel spikes. Despite the high noise correlation, decoders using LFPs in addition to spikes outperformed decoders using only spikes. Significance. These results demonstrate that multichannel LFPs could effectively complement spikes for BMI applications by yielding more informative channels. The utility of multichannel LFPs may be further augmented if their high noise correlation can be taken into account by decoders.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1088/1741-2560/10/4/046005DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731147PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Alternate Title:The Utility of Multichannel LFPs for Brain-Machine Interfaces
Additional Information:© 2013 Institute of Physics. Received 11 February 2013. Accepted for publication 21 May 2013. Published 7 June 2013. This work was supported by NIH grant EY013337 and DARPA award N66001-10-C-2009. EJH was supported by NIH Career Development Award K99 NS062894. We thank Spencer Kellis, Arnulf Graf, Boris Revechkis, and Bardia Behabadi for scientific discussion, Tessa Yao for editorial assistance, Kelsie Pejsa for animal care, and Viktor Shcherbatyuk for technical assistance.
Funders:
Funding AgencyGrant Number
NIHEY013337
Defense Advanced Research Projects Agency (DARPA)N66001-10-C-2009
NIHK99 NS062894
Issue or Number:4
Classification Code:PACS: 87.85.J-, 87.85.Ng, 87.19.L-, 87.19.R-
PubMed Central ID:PMC3731147
DOI:10.1088/1741-2560/10/4/046005
Record Number:CaltechAUTHORS:20131001-084826145
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131001-084826145
Official Citation:The utility of multichannel local field potentials for brain–machine interfaces Eun Jung Hwang and Richard A Andersen 2013 J. Neural Eng. 10 046005
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41587
Collection:CaltechAUTHORS
Deposited By:INVALID USER
Deposited On:01 Oct 2013 22:50
Last Modified:10 Nov 2021 04:32

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