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Antibodies in HIV-1 Vaccine Development and Therapy

Klein, Florian and Mouquet, Hugo and Dosenovic, Pia and Scheid, Johannes F. and Scharf, Louise and Nussenzweig, Michel C. (2013) Antibodies in HIV-1 Vaccine Development and Therapy. Science, 341 (6151). pp. 1199-1204. ISSN 0036-8075. PMCID PMC3970325. https://resolver.caltech.edu/CaltechAUTHORS:20131010-092934615

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Abstract

Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered naturally arising, broad and potent HIV-1–neutralizing antibodies (bNAbs). These antibodies can protect against infection and suppress established HIV-1 infection in animal models. The finding that these antibodies develop in a fraction of infected individuals supports the idea that new approaches to vaccination might be developed by adapting the natural immune strategies or by structure-based immunogen design. Moreover, the success of passive immunotherapy in small-animal models suggests that bNAbs may become a valuable addition to the armamentarium of drugs that work against HIV-1.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1241144 DOIArticle
http://www.sciencemag.org/content/341/6151/1199PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970325/PubMed CentralArticle
ORCID:
AuthorORCID
Nussenzweig, Michel C.0000-0003-0592-8564
Additional Information:© 2013 American Association for the Advancement of Science. We thank members of the Bjorkman and Nussenzweig laboratories for discussion. F.K. was supported by the Stavros Niarchos and the Robert Mapplethorpe Foundation, H.M. by the Milieu Intérieur project ANR-10-LABX-69-01, P.D. by an International postdoc fellowship from the Swedish Research Council, and L.S. by the American Cancer Society Grant PF-13-076-01-MPC. This work was supported in part by the Bill and Melinda Gates Foundation and NIH awards UM1AI100663, AI 100663-01, and AI 100148-01 to M.C.N. M.C.N. is a HHMI investigator.
Funders:
Funding AgencyGrant Number
Stavros Niarchos FoundationUNSPECIFIED
Robert Mapplethorpe FoundationUNSPECIFIED
Milieu Intérieur ProjectANR-10-LABX-69-01
Swedish Research CouncilUNSPECIFIED
American Cancer SocietyPF-13-076-01-MPC
Bill and Melinda Gates FoundationUNSPECIFIED
NIHUM1AI100663
NIHAI 100663-01
NIHAI 100148-01
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:6151
PubMed Central ID:PMC3970325
Record Number:CaltechAUTHORS:20131010-092934615
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131010-092934615
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:41859
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Oct 2013 16:49
Last Modified:03 Oct 2019 05:52

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