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Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior

Shmiel, Tomer and Drori, Rotem and Shmiel, Oren and Ben-Shaul, Yoram and Nadasdy, Zoltan and Shemesh, Moshe and Teicher, Mina and Abeles, Moshe (2005) Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior. Proceedings of the National Academy of Sciences of the United States of America, 102 (51). pp. 18655-18657. ISSN 0027-8424. PMCID PMC1317975. doi:10.1073/pnas.0509346102.

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We show that times of spikes can be very precise. In the cerebral cortex, where each nerve cell is affected by thousands of others, it is the common belief that the exact time of a spike is random up to an averaged firing rate over tens of milliseconds. in a brain slice, precise time relations of several neurons have been observed. It remained unclear whether this phenomenon can also be observed in brains of behaving animals. Here we show, in behaving monkeys, that time intervals between spikes, measured in correspondence to a specific behavior, may be controlled to within the milliseconds range.

Item Type:Article
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URLURL TypeDescription CentralArticle
Ben-Shaul, Yoram0000-0002-0407-4221
Additional Information:© 2005 by The National Academy of Sciences of the USA. Communicated by Hyman Bass, University of Michigan, Ann Arbor, MI, October 28, 2005 (received for review February 7, 2005). Published online before print December 9, 2005, 10.1073/pnas.0509346102. This work was supported in part by grants from the Israel Science Foundation, the German–Israel Foundation, the Deutsch–Israelische Projectkooperation, the Horowitz Fund, and the RICH center. M.A. is a Shamoon professor at Bar-Ilan University.
Funding AgencyGrant Number
Israel Science FoundationUNSPECIFIED
German-Israeli Foundation for Research and DevelopmentUNSPECIFIED
Bar-Ilan UniversityUNSPECIFIED
Subject Keywords:data mining; motor cortex; neural codes; precise timing; single units
Issue or Number:51
PubMed Central ID:PMC1317975
Record Number:CaltechAUTHORS:SHMpnas05
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4198
Deposited By: Tony Diaz
Deposited On:07 Aug 2006
Last Modified:08 Nov 2021 20:15

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