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In-vitro investigation of a potential wave pumping effect in human aorta

Pahlevan, Niema M. and Gharib, Morteza (2013) In-vitro investigation of a potential wave pumping effect in human aorta. Journal of Biomechanics, 46 (13). pp. 2122-2129. ISSN 0021-9290 . https://resolver.caltech.edu/CaltechAUTHORS:20131024-100913490

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Abstract

An impedance pump – also known as Liebau pump – is a simple valveless pump that operates based on the principles of wave propagation and reflection. It has been shown in embryonic zebrafish that a similar mechanism is responsible for the pumping action in the embryonic heart during the early stages before valve formation. Recent studies suggest that the cardiovascular system is designed to take advantage of wave propagation and reflection phenomena in the arterial network. In this study we report the results of an in-vitro study that examines the hypothesis that the adult human aorta acts as a passive pump based on Liebau effect. A hydraulic model with different compliant models of an artificial aorta was used for a series of in-vitro experiments. Our result indicates that wave propagation and reflection can result in a pumping mechanism in a compliant aorta.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jbiomech.2013.07.006 DOIArticle
http://www.sciencedirect.com/science/article/pii/S0021929013003175PublisherArticle
Additional Information:© 2013 Elsevier Ltd. Accepted 4 July 2013. N.M. Pahlevan acknowledges support from the American Heart Association (AHA) Predoctoral fellowship.
Group:GALCIT
Funders:
Funding AgencyGrant Number
American Heart Association (AHA) Predoctoral FellowshipUNSPECIFIED
Subject Keywords:Aortic waves; Impedance pump; Liebau effect; Left ventricular workload; Arterial wave reflection
Issue or Number:13
Record Number:CaltechAUTHORS:20131024-100913490
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131024-100913490
Official Citation:Niema M. Pahlevan, Morteza Gharib, In-vitro investigation of a potential wave pumping effect in human aorta, Journal of Biomechanics, Volume 46, Issue 13, 3 September 2013, Pages 2122-2129, ISSN 0021-9290, http://dx.doi.org/10.1016/j.jbiomech.2013.07.006. (http://www.sciencedirect.com/science/article/pii/S0021929013003175)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42040
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Oct 2013 22:15
Last Modified:03 Oct 2019 05:54

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