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A Novel Precision-Engineered Membrane Microfiltration Device for Capture and Characterization of Bladder Cancer Cells in Urine

Mitra, Anirban P. and Birkhahn, Marc and Williams, Anthony J. and Barr, Nancy J. and Skinner, Eila C. and Stein, John P. and Skinner, Donald G. and Tai, Yu C. and Datar, Ram H. and Cote, Richard J. (2012) A Novel Precision-Engineered Membrane Microfiltration Device for Capture and Characterization of Bladder Cancer Cells in Urine. Journal of Urology, 187 (4). E517. ISSN 0022-5347. http://resolver.caltech.edu/CaltechAUTHORS:20131024-144444129

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Abstract

Non-invasive bladder cancer (BC) detection techniques including standard urine cytology have been unable to substitute or reduce the need for cystoscopy due to several limitations: inadequate sensitivity (often due to paucicellular specimens), ability and tendency to examine only a partial specimen, and presence of confounding background non-urothelial cells. Patients may therefore benefit from an alternative sensitive, rapid and cost-effective BC detection and surveillance assay. This study evaluated the performance and practical applicability of a novel portable membrane microfiltration device for capture, enumeration and characterization of exfoliated tumor cells in urine, and compared it with standard urine cytology for BC detection.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.jurology.com/article/S0022-5347%2812%2901970-2/fulltextPublisherArticle
http://dx.doi.org/10.1016/j.juro.2012.02.1608DOIArticle
ORCID:
AuthorORCID
Tai, Yu C.0000-0001-8529-106X
Additional Information:© 2012 Elsevier Inc.
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Funding AgencyGrant Number
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Record Number:CaltechAUTHORS:20131024-144444129
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20131024-144444129
Official Citation:1276 A NOVEL PRECISION-ENGINEERED MEMBRANE MICROFILTRATION DEVICE FOR CAPTURE AND CHARACTERIZATION OF BLADDER CANCER CELLS IN URINE Anirban P. Mitra, Marc Birkhahn, Anthony J. Williams, Nancy J. Barr, Eila C. Skinner, John P. Stein, Donald G. Skinner, Yu C. Tai, Ram H. Datar, Richard J. Cote The Journal of urology 1 April 2012 (volume 187 issue 4 Page e517 DOI: 10.1016/j.juro.2012.02.1608)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42053
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Oct 2013 22:13
Last Modified:17 May 2017 21:01

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