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Intraduplex DNA-Mediated Electrochemistry of Covalently Tethered Redox-Active Reporters

Pheeney, Catrina G. and Barton, Jacqueline K. (2013) Intraduplex DNA-Mediated Electrochemistry of Covalently Tethered Redox-Active Reporters. Journal of the American Chemical Society, 135 (40). pp. 14944-14947. ISSN 0002-7863. PMCID PMC3899830. http://resolver.caltech.edu/CaltechAUTHORS:20131105-140620927

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Abstract

Intraduplex DNA-mediated reduction is established as a general mechanism for the reduction of distally bound stacked redox-active species covalently tethered to DNA through flexible alkane linkages. Methylene Blue (MB), Nile Blue (NB), and Anthraquinone (AQ) were covalently tethered to DNA with three different covalent linkages. Using these reporters DNA electrochemistry was shown to be both DNA-mediated and intra-, rather than inter-, duplex. Significantly, the charge transport pathway occurring through the DNA π-stack is established by using an intervening AC mismatch to break this path. The fact that the DNA-mediated reduction of MB occurs primarily via intraduplex intercalation is established through varying the proximity and integrity of the neighboring duplex DNA.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://pubs.acs.org/doi/abs/10.1021/ja408135gPublisherArticle
http://dx.doi.org/10.1021/ja408135gDOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899830/PubMed CentralArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2013 American Chemical Society. Publication Date (Web): September 30, 2013. Received: August 6, 2013. We are grateful for the support of NIH (GM61077). We also thank the Kavli Nanoscience Institute facilities and staff for help in fabricating the multiplexed chips. The authors declare no competing financial interest.
Group:Kavli Nanoscience Institute
Funders:
Funding AgencyGrant Number
NIHGM61077
PubMed Central ID:PMC3899830
Record Number:CaltechAUTHORS:20131105-140620927
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20131105-140620927
Official Citation:Intraduplex DNA-Mediated Electrochemistry of Covalently Tethered Redox-Active Reporters Catrina G. Pheeney and Jacqueline K. Barton Journal of the American Chemical Society 2013 135 (40), 14944-14947
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42255
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Nov 2013 23:38
Last Modified:25 Jan 2016 20:08

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