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Extracellular field signatures of CA1 spiking cell assemblies during sharp wave-ripple complexes

Taxidis, Jiannis and Diba, Kamran and Anastassiou, Costas A. and Buzsáki, György and Koch, Christof (2013) Extracellular field signatures of CA1 spiking cell assemblies during sharp wave-ripple complexes. BMC Neuroscience, 14 (S1). Art. No. O14. ISSN 1471-2202. https://resolver.caltech.edu/CaltechAUTHORS:20131107-132510621

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Abstract

Although postsynaptic and transmembrane currents over local neuronal populations are considered the main factors for shaping local field potential (LFP) and current source density (CSD) fluctuations [1], high-frequency oscillatory LFPs can also be shaped by extracellular action potentials of pyramidal cell populations [2]. Sharp wave-ripple complexes (SWRs) are typical examples of such high-frequency oscillatory events, observed in hippocampal LFPs during deep sleep and awake immobility. They consist of an extensive depolarization in the CA1 dendritic layer (sharp wave) arising from population bursts in CA3, accompanied by a ~150-200 Hz LFP oscillation in the CA1 pyramidal layer (ripple). During SWRs, temporal firing patterns of correlated place cells, acquired during wakeful exploration, are replayed in fast-scale, providing a strong indication for the participation of SWRs in memory consolidation. Yet the particular effects of these pattern replays on the hippocampal extracellular field are largely unknown. How are the different ensembles of spiking cells encoded in the emerging ripple-LFPs? Here, we study this association through both a modeling and an experimental approach.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.biomedcentral.com/1471-2202/14/S1/O14PublisherArticle
http://dx.doi.org/10.1186/1471-2202-14-S1-O14DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704589/PubMed CentralArticle
ORCID:
AuthorORCID
Anastassiou, Costas A.0000-0002-6793-0611
Koch, Christof0000-0001-6482-8067
Additional Information:© 2013 Taxidis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Published: 8 July 2013.
Issue or Number:S1
Record Number:CaltechAUTHORS:20131107-132510621
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131107-132510621
Official Citation:Taxidis et al.: Extracellular field signatures of CA1 spiking cell assemblies during sharp wave-ripple complexes. BMC Neuroscience 2013 14(Suppl 1):
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42306
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Nov 2013 22:01
Last Modified:09 Mar 2020 13:18

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