CaltechAUTHORS
  A Caltech Library Service

Comparison of the effects of millimeter wave irradiation, general bath heating, and localized heating on neuronal activity in the leech ganglion

Romanenko, Sergii and Siegel, Peter H. and Wagenaar, Daniel A. and Pikov, Victor (2013) Comparison of the effects of millimeter wave irradiation, general bath heating, and localized heating on neuronal activity in the leech ganglion. In: Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications. Proceedings of SPIE. No.8585. Society of Photo-Optical Engineers , Bellingham, WA, Art. No. 85850N. ISBN 978-0-8194-9354-5. https://resolver.caltech.edu/CaltechAUTHORS:20131111-140845262

[img]
Preview
PDF - Published Version
See Usage Policy.

708Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20131111-140845262

Abstract

The use of electrically-induced neuromodulation has grown in importance in the treatment of multiple neurological disorders such as Parkinson’s disease, dystonia, epilepsy, chronic pain, cluster headaches and others. While electrical current can be applied locally, it requires placing stimulation electrodes in direct contact with the neural tissue. Our goal is to develop a method for localized application of electromagnetic energy to the brain without direct tissue contact. Toward this goal, we are experimenting with the wireless transmission of millimeter wave (MMW) energy in the 10-100 GHz frequency range, where penetration and focusing can be traded off to provide non-contact irradiation of the cerebral cortex. Initial experiments have been conducted on freshly-isolated leech ganglia to evaluate the real-time changes in the activity of individual neurons upon exposure to the MMW radiation. The initial results indicate that low-intensity MMWs can partially suppress the neuronal activity. This is in contrast to general bath heating, which had an excitatory effect on the neuronal activity. Further studies are underway to determine the changes in the state of the membrane channels that might be responsible for the observed neuromodulatory effects. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.2006504DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1656385PublisherArticle
ORCID:
AuthorORCID
Siegel, Peter H.0000-0002-2539-4646
Wagenaar, Daniel A.0000-0002-6222-761X
Additional Information:© 2013 SPIE.
Subject Keywords:Neuron; action potential; leech; millimeter waves; non-invasive; brain; GHz; terahertz
Series Name:Proceedings of SPIE
Issue or Number:8585
Record Number:CaltechAUTHORS:20131111-140845262
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131111-140845262
Official Citation:Sergii Romanenko ; Peter H. Siegel ; Daniel A. Wagenaar and Victor Pikov " Comparison of the effects of millimeter wave irradiation, general bath heating, and localized heating on neuronal activity in the leech ganglion ", Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850N (February 23, 2013); doi:10.1117/12.2006504
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42356
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:13 Nov 2013 20:24
Last Modified:09 Mar 2020 13:19

Repository Staff Only: item control page