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Feasibility Study of Carbon Nanotube Microneedles for Rapid Transdermal Drug Delivery

Lyon, Bradley J. and Aria, Adrianus I. and Gharib, Morteza (2013) Feasibility Study of Carbon Nanotube Microneedles for Rapid Transdermal Drug Delivery. MRS Proceedings, 1569 . ISSN 1946-4274. https://resolver.caltech.edu/CaltechAUTHORS:20131118-091418305

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Abstract

We introduce a new approach for fabricating hollow microneedles using vertically-aligned carbon nanotubes (VA-CNTs) for rapid transdermal drug delivery. Here, we discuss the fabrication of the microneedles emphasizing the overall simplicity and flexibility of the method to allow for potential industrial application. By capitalizing on the nanoporosity of the CNT bundles, uncured polymer can be wicked into the needles ultimately creating a high strength composite of aligned nanotubes and polymer. Flow through the microneedles as well as in vitro penetration of the microneedles into swine skin is demonstrated. Furthermore, we present a trade study comparing the difficulty and complexity of the fabrication process of our CNT-polymer microneedles with other standard microneedle fabrication approaches.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1557/opl.2013.803DOIArticle
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8943507PublisherArticle
http://www.mrs.org/spring2013/OrganizationConference website
Additional Information:© 2013 Materials Research Society. We acknowledge Zcube s.r.l for their financial support of this work. We also acknowledge the Kavli Nanoscience Institute and the Geology and Planetary Sciences Analytical Facility for their support in running experiments.
Group:Kavli Nanoscience Institute, GALCIT
Funders:
Funding AgencyGrant Number
Zcube s.r.l.UNSPECIFIED
Subject Keywords:biomedical; C; composite
Record Number:CaltechAUTHORS:20131118-091418305
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131118-091418305
Official Citation:Feasibility Study of Carbon Nanotube Microneedles for Rapid Transdermal Drug Delivery Bradley J. Lyon, Adrianus I. Aria and Morteza Gharib MRS Proceedings / Volume 1569 / 2013 Copyright © Materials Research Society 2013 DOI: http://dx.doi.org/10.1557/opl.2013.803
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42516
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:18 Nov 2013 17:49
Last Modified:03 Oct 2019 05:59

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