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Engineering an HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly Neutralizing VRC01-Class Antibodies

McGuire, A. and Dreyer, A. M. and Hoot, S. and Lippy, A. and Stuart, A. and Cohen, K. W. and Jardine, J. and Menis, S. and Scheid, J. F. and West, A. P., Jr. and Schief, W. R. and Stamatatos, L. (2013) Engineering an HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly Neutralizing VRC01-Class Antibodies. AIDS Research and Human Retroviruses, 29 (11). A6. ISSN 0889-2229. https://resolver.caltech.edu/CaltechAUTHORS:20131122-084031728

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Abstract

The recent RV144 trial showed ~30% efficacy. Although the protection was modest, the trial indicated for the first time that a vaccine against HIV is possible. Immune correlate analysis suggests that the observed protection was due to non-neutralizing antibody responses. This efficacy might be improved if a vaccine could elicit broadly neutralizing antibodies (bNAbs). Of particular interest for vaccine design are the potent VRC01- class bNAbs targeting CD4 binding site on Env. Unfortunately, a number of studies have demonstrated that recombinant Env proteins do not bind germline-reverted VRC01 class Abs, indicating that current vaccine strategies using recombinant Env are unable to activate progenitor B cells that ultimately give rise to VRC01 class Abs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1089/aid.2013.1500DOIAbstracts
http://online.liebertpub.com/doi/abs/10.1089/aid.2013.1500PublisherAbstracts
Additional Information:© 2013 Mary Ann Liebert, Inc. publishers. Published in Volume: 29 Issue 11: October 24, 2013. Online Ahead of Print: October 10, 2013.
Issue or Number:11
Record Number:CaltechAUTHORS:20131122-084031728
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131122-084031728
Official Citation:AIDS Research and Human Retroviruses. November 2013, 29(11): A-1-A-208. doi:10.1089/aid.2013.1500
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42641
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Nov 2013 00:42
Last Modified:03 Oct 2019 06:00

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