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Structural Basis for HIV-1 gp120 Recognition by a Germ-line Version of a Broadly Neutralizing Antibody

Scharf, L. and West, A. P. and Scheid, J. F. and Nussenzweig, M. C. and Bjorkman, P. J. and Diskin, R. (2013) Structural Basis for HIV-1 gp120 Recognition by a Germ-line Version of a Broadly Neutralizing Antibody. AIDS Research and Human Retroviruses, 29 (11). A11-A12. ISSN 0889-2229.

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Following infection by HIV-1, the host immune response is unable to clear the virus due to a variety of factors, including rapid viral mutation and the establishment of latent reservoirs. The only target of neutralizing antibodies is the trimeric envelope (Env) spike complex, but HIV-1 can usually evade anti-spike antibodies due to rapid mutation of its two spike glycoproteins, gp120 and gp41, and structural features that allow the spike to hide conserved epitopes. Efforts to design an effective antibody-based vaccine against HIV-1 would benefit from understanding how germ-line B-cell receptors recognize the gp120/ gp41 envelope spike. Recently isolated from several infected individuals, potent VRC01-like (PVL) HIV-1 antibodies derived from the VH1–2*02 germ-line allele target the CD4 binding site on gp120. These antibodies have unprecedented potency and breadth for HIV-1 neutralization and some protect against HIV-1 infection in animal models. Since the VH1–2*02 germ-line allele is present in up to 95% of the population, it may be possible to elicit by vaccination similar CD4 binding site antibodies in other individuals. VH1–2*02 germ-line B-cell receptor interactions with gp120 were uncharacterized, which was a bottleneck for designing immunogens to elicit PVL antibodies.

Item Type:Article
Related URLs:
URLURL TypeDescription
Nussenzweig, M. C.0000-0003-0592-8564
Bjorkman, P. J.0000-0002-2277-3990
Diskin, R.0000-0002-2837-5897
Additional Information:© 2013 Mary Ann Liebert, Inc. publishers. Published in Volume: 29 Issue 11: October 24, 2013. Online Ahead of Print: October 10, 2013.
Issue or Number:11
Record Number:CaltechAUTHORS:20131122-103725550
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Official Citation:AIDS Research and Human Retroviruses. November 2013, 29(11): A-1-A-208. doi:10.1089/aid.2013.1500
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42651
Deposited By: Tony Diaz
Deposited On:24 Nov 2013 00:39
Last Modified:03 Oct 2019 06:00

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