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Tailored Glycopolymers as Anticoagulant Heparin Mimetics

Oh, Young In and Sheng, Gloria J. and Chang, Shuh-Kuen and Hsieh-Wilson, Linda C. (2013) Tailored Glycopolymers as Anticoagulant Heparin Mimetics. Angewandte Chemie International Edition, 52 (45). pp. 11796-11799. ISSN 1433-7851. PMCID PMC3943734. https://resolver.caltech.edu/CaltechAUTHORS:20131203-081421669

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Abstract

Not to clot: Heparin and its low-molecular-weight derivatives are clinical therapeutics used to treat and prevent blood clots. The synthesis of heparin-based glycopolymers that are potent and potentially safer mimetics of heparin is described. The mimetics exhibited activity against proteases (FXa and FIIa) in the coagulation cascade and prolonged blood clot times in human plasma with efficacies similar to those of clinical anticoagulants. ATIII=antithrombin III.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/anie.201306968 DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.201306968/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943734/PubMed CentralArticle
ORCID:
AuthorORCID
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: August 8, 2013; Published online: October 9, 2013. We thank Prof. Robert H. Grubbs and Dr. Jean Li for their generous donation of the ruthenium catalyst and for helpful discussions. This research was supported by National Institutes of Health grant R01 GM093627 (L.H.W.).
Funders:
Funding AgencyGrant Number
NIHR01 GM093627
Subject Keywords:anticoagulant; biomimetic synthesis; drug discovery; glycopolymers; heparin
Issue or Number:45
PubMed Central ID:PMC3943734
Record Number:CaltechAUTHORS:20131203-081421669
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131203-081421669
Official Citation:Oh, Y. I., Sheng, G. J., Chang, S.-K. and Hsieh-Wilson, L. C. (2013), Tailored Glycopolymers as Anticoagulant Heparin Mimetics. Angew. Chem. Int. Ed., 52: 11796–11799. doi: 10.1002/anie.201306968
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42784
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Dec 2013 16:53
Last Modified:03 Oct 2019 06:01

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