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Feed Your Head: Neurodevelopmental Control of Feeding and Metabolism

Lee, Daniel A. and Blackshaw, Seth (2014) Feed Your Head: Neurodevelopmental Control of Feeding and Metabolism. Annual Review of Physiology, 76 . pp. 197-223. ISSN 0066-4278. PMCID PMC4512170. doi:10.1146/annurev-physiol-021113-170347. https://resolver.caltech.edu/CaltechAUTHORS:20131203-153902408

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Abstract

During critical periods of development early in life, excessive or scarce nutritional environments can disrupt the development of central feeding and metabolic neural circuitry, leading to obesity and metabolic disorders in adulthood. A better understanding of the genetic networks that control the development of feeding and metabolic neural circuits, along with knowledge of how and where dietary signals disrupt this process, can serve as the basis for future therapies aimed at reversing the public health crisis that is now building as a result of the global obesity epidemic. This review of animal and human studies highlights recent insights into the molecular mechanisms that regulate the development of central feeding circuitries, the mechanisms by which gestational and early postnatal nutritional status affects this process, and approaches aimed at counteracting the deleterious effects of early over-and underfeeding.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev-physiol-021113-170347DOIArticle
http://www.annualreviews.org/doi/abs/10.1146/annurev-physiol-021113-170347PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512170PubMed CentralArticle
ORCID:
AuthorORCID
Lee, Daniel A.0000-0001-7411-2740
Additional Information:© 2014 Annual Reviews. Review in Advance first posted online on November 18, 2013. We thank W. Yap, T. Moran, and J. Bedont for helpful feedback on the manuscript.
Subject Keywords:obesity, diabetes, neural circuits, neurogenesis, hypothalamus, diet
PubMed Central ID:PMC4512170
DOI:10.1146/annurev-physiol-021113-170347
Record Number:CaltechAUTHORS:20131203-153902408
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131203-153902408
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42810
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Dec 2013 00:00
Last Modified:10 Nov 2021 16:28

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