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A Chemical Epitope-Targeting Strategy for Protein Capture Agents: The Serine 474 Epitope of the Kinase Akt2

Nag, Arundhati and Das, Samir and Yu, Mary Beth and Deyle, Kaycie M. and Millward, Steven W. and Heath, James R. (2013) A Chemical Epitope-Targeting Strategy for Protein Capture Agents: The Serine 474 Epitope of the Kinase Akt2. Angewandte Chemie International Edition, 52 (52). pp. 13975-13979. ISSN 1433-7851. PMCID PMC4059071. https://resolver.caltech.edu/CaltechAUTHORS:20131204-154453202

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Abstract

Target and click: Peptide ligands targeted to the C-terminal motif of the kinase Akt2 were obtained by combining phosphate recognition of a dinuclear zinc(II) complex with in situ click chemistry to target this epitope. The peptide ligands (shown as XXXXX) selectively bind the C-terminal polypeptide of Akt2, and are selective for Akt2 relative to the Akt1 and Akt3 isoforms. The ligands differentially modulate Akt2 activity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/anie.201305882DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.201305882/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059071/PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: July 7, 2013; Revised: September 23, 2013. Article first published online: 19 Nov. 2013. This work was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office. Additional personnel or facilities support from the National Cancer Institute (5U54 CA119347: J.R.H. PI), the Grand Duchy of Luxembourg, and the Bill and Melinda Gates Foundation is acknowledged.
Funders:
Funding AgencyGrant Number
Army Research Office (ARO)W911NF-09-0001
NIH5U54 CA119347
Grand Duchy of LuxembourgUNSPECIFIED
Bill and Melinda Gates FoundationUNSPECIFIED
National Cancer InstituteUNSPECIFIED
Subject Keywords:click chemistry; drug design; inhibitors; kinases; peptides
Issue or Number:52
PubMed Central ID:PMC4059071
Record Number:CaltechAUTHORS:20131204-154453202
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131204-154453202
Official Citation:Nag, A., Das, S., Yu, M. B., Deyle, K. M., Millward, S. W. and Heath, J. R. (2013), A Chemical Epitope-Targeting Strategy for Protein Capture Agents: The Serine 474 Epitope of the Kinase Akt2. Angew. Chem. Int. Ed., 52: 13975–13979. doi: 10.1002/anie.201305882
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42839
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Dec 2013 00:38
Last Modified:03 Oct 2019 06:02

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