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The autodestruction of pepsin in relation to its ionization

Goulding, Arthur M. and Borsook, Henry and Wasteneys, Hardolph (1927) The autodestruction of pepsin in relation to its ionization. Journal of General Physiology, 10 (3). pp. 451-467. ISSN 0022-1295. https://resolver.caltech.edu/CaltechAUTHORS:20131204-160039218

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Abstract

1. Evidence is presented that pepsin is a univalent acid with a value for pK of 6.85 (or a base, with pK 7.39). 2. The autodestruction of the pepsin is shown to be dependent in part upon an instantaneous irreversible change occurring in the ionized form of the enzyme (if it be an acid) or in the unionized form (if it be a base). 3. A further progressive autodestruction of pepsin at any given hydrogen ion concentration and temperature is defined by the mass law equation for a monomolecular reaction 4. The velocity of autodestruction of pepsin is directly proportional to the hydroxyl ion concentration. It is much less in the range of hydroxyl ion concentration from pOH 9.89-7.7, than in the range greater than pOH 7.7. In both of these ranges variations in pK with pOH may be represented by straight lines.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1085/jgp.10.3.451 DOIArticle
http://jgp.rupress.org/content/10/3/451PublisherArticle
Additional Information:© 1927 Rockefeller University Press. Accepted: 30 September 1926. Published January 20, 1927. The authors wish to thank Mr. M. H. Centner for his generous assistance with numerous analyses.
Issue or Number:3
Record Number:CaltechAUTHORS:20131204-160039218
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20131204-160039218
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42841
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Dec 2013 00:41
Last Modified:03 Oct 2019 06:02

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