Hsiao, Elaine Y. (2013) Immune Dysregulation in Autism Spectrum Disorder. In: Neurobiology of Autism. International Review of Neurobiology . No.113. Elsevier , pp. 269-302. ISBN 978-0-12-418700-9. https://resolver.caltech.edu/CaltechAUTHORS:20131210-102332132
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Abstract
Autism spectrum disorder (ASD) is a highly heterogeneous disorder diagnosed based on the presence and severity of core abnormalities in social communication and repetitive behavior, yet several studies converge on immune dysregulation as a feature of ASD. Widespread alterations in immune molecules and responses are seen in the brains and periphery of ASD individuals, and early life immune disruptions are associated with ASD. This chapter discusses immune-related environmental and genetic risk factors for ASD, emphasizing population-wide studies and animal research that reveal potential mechanistic pathways involved in the development of ASD-related symptoms. It further reviews immunologic pathologies seen in ASD individuals and how such abnormalities can impact neurodevelopment and behavior. Finally, it evaluates emerging evidence for an immune contribution to the pathogenesis of ASD and a potential role for immunomodulatory effects in current treatments for ASD.
| Item Type: | Book Section | ||||||
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| Additional Information: | © 2013 Elsevier Inc. | ||||||
| Subject Keywords: | Neurodevelopment; Immunity; Maternal infection; Autoantibody; Microglia; Cytokine | ||||||
| Series Name: | International Review of Neurobiology | ||||||
| Issue or Number: | 113 | ||||||
| DOI: | 10.1016/B978-0-12-418700-9.00009-5 | ||||||
| Record Number: | CaltechAUTHORS:20131210-102332132 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20131210-102332132 | ||||||
| Official Citation: | Elaine Y. Hsiao, Chapter Nine - Immune Dysregulation in Autism Spectrum Disorder, In: Genevieve Konopka, Editor(s), International Review of Neurobiology, Academic Press, 2013, Volume 113, Pages 269-302, ISSN 0074-7742, ISBN 9780124187009, http://dx.doi.org/10.1016/B978-0-12-418700-9.00009-5. (http://www.sciencedirect.com/science/article/pii/B9780124187009000095) | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 42920 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 23 Dec 2013 21:02 | ||||||
| Last Modified: | 10 Nov 2021 16:30 |
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