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Immune Dysregulation in Autism Spectrum Disorder

Hsiao, Elaine Y. (2013) Immune Dysregulation in Autism Spectrum Disorder. In: Neurobiology of Autism. International Review of Neurobiology . No.113. Elsevier , pp. 269-302. ISBN 978-0-12-418700-9.

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Autism spectrum disorder (ASD) is a highly heterogeneous disorder diagnosed based on the presence and severity of core abnormalities in social communication and repetitive behavior, yet several studies converge on immune dysregulation as a feature of ASD. Widespread alterations in immune molecules and responses are seen in the brains and periphery of ASD individuals, and early life immune disruptions are associated with ASD. This chapter discusses immune-related environmental and genetic risk factors for ASD, emphasizing population-wide studies and animal research that reveal potential mechanistic pathways involved in the development of ASD-related symptoms. It further reviews immunologic pathologies seen in ASD individuals and how such abnormalities can impact neurodevelopment and behavior. Finally, it evaluates emerging evidence for an immune contribution to the pathogenesis of ASD and a potential role for immunomodulatory effects in current treatments for ASD.

Item Type:Book Section
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Hsiao, Elaine Y.0000-0002-1633-588X
Additional Information:© 2013 Elsevier Inc.
Subject Keywords:Neurodevelopment; Immunity; Maternal infection; Autoantibody; Microglia; Cytokine
Series Name:International Review of Neurobiology
Issue or Number:113
Record Number:CaltechAUTHORS:20131210-102332132
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Official Citation:Elaine Y. Hsiao, Chapter Nine - Immune Dysregulation in Autism Spectrum Disorder, In: Genevieve Konopka, Editor(s), International Review of Neurobiology, Academic Press, 2013, Volume 113, Pages 269-302, ISSN 0074-7742, ISBN 9780124187009, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42920
Deposited By: Tony Diaz
Deposited On:23 Dec 2013 21:02
Last Modified:10 Nov 2021 16:30

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